Protein Information

Name 5 HT1A
Synonyms 5 HT 1A; serotonin receptor; 5 HT1A; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine 1A receptor; 5HT1A; ADRB2RL1; ADRBRL 1…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19762159 Gomez-Gil E, Navines R, Martinez De Osaba MJ, Diaz-Ricart M, Escolar G, Salamero M, Martin-Santos R, Galan A, Gasto C: Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment. Psychoneuroendocrinology. 2010 May;35(4):481-9. Epub 2009 Sep 16.

6(0,0,0,6) Details
16035959 Rossi DV, Valdez M, Gould GG, Hensler JG: Chronic administration of venlafaxine fails to attenuate 5-HT1A receptor function at the level of receptor-G protein interaction. Int J Neuropsychopharmacol. 2006 Aug;9(4):393-406. Epub 2005 Jul 22.


We evaluated, using quantitative autoradiography, the effect of these antidepressant treatments on [35S] GTPgammaS binding stimulated by the 5-HT1A receptor agonist 8-OH-DPAT, a measure of the capacity of 5-HT1A receptors to activate G proteins.
2(0,0,0,2) Details
12422559 Bourin M, David DJ, Jolliet P, Gardier A: [Mechanism of action of antidepressants and therapeutic perspectives] . Therapie. 2002 Jul-Aug;57(4):385-96.


Behavioural, electrophysiological and microdialysis studies have shown that serotonin (5-HT) receptors, mainly 5-HT1A, 5-HT1B and 5-HT2C sub-types, exert a key role in modulating antidepressant activity.
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