Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16351573 Guo H, Gao C, Mi Z, Wai PY, Kuo PC: Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochem J. 2006 Mar 1;394(Pt 2):379-87.


In vitro phosphorylation and kinase inhibitor studies implicate p38 kinase activity.
2(0,0,0,2) Details
17380379 Beretti F, Cenacchi V, Portolani M, Ardizzoni A, Blasi E, Cermelli C: A transmissible cytotoxic activity isolated from a patient with brain ischemia causes microglial cell activation and dysfunction. Cell Mol Neurobiol. 2007 Jun;27(4):517-28. Epub 2007 Mar 23.


The murine microglial cell line RR4 was exposed to TCA, and then its response was evaluated as: (a) phagocytosis and antifungal activity against Candida albicans; (b) secretory pattern; and (c) levels of p38 phosphorylation.3.
1(0,0,0,1) Details
19298531 Chen DD, Dong YG, Liu D, He JG: Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats. Clin Exp Pharmacol Physiol. 2009 Mar 2.


The phosphorylations of ERK2, p38, and JNK1 were significantly increased in left ventricle of EGCG treated TCA rats, accompanied with activations of NF-kappaB and AP-1.
1(0,0,0,1) Details
18519664 Cervera AM, Apostolova N, Crespo FL, Mata M, McCreath KJ: Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res. 2008 Jun 1;68(11):4058-67.


In addition, the c-Jun amino-terminal kinase and p38 kinase stress signaling proteins were hyperphosphorylated in SDHB-silenced cells.
1(0,0,0,1) Details