Protein Information

Name GLUT1
Synonyms Erythrocyte/hepatoma glucose transporter; GLUT; GLUT 1; GLUT1; Glucose transporter 1; HepG2 glucose transporter; SLC2A1; Glucose transporter 1s…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19631691 Devraj K, Geguchadze R, Klinger ME, Freeman WM, Mokashi A, Hawkins RA, Simpson IA: Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein. J Neurosci Methods. 2009 Oct 30;184(1):119-23. Epub 2009 Jul 23.

5(0,0,0,5) Details
12169439 Hall JL, Gibbons GH, Chatham JC: IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells. . Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E465-71.


Previous work in our laboratory identified an increase in GLUT1 content and glucose metabolism in neointimal VSMC that was sufficient to promote proliferation and inhibit apoptosis.
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19401345 Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ: Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res. 2009 May 15;15(10):3442-50. Epub 2009 Apr 28.


The changes in glucose uptake and metabolism were accompanied by intracellular translocation of GLUT-1 from the plasma membrane into the intracellular fraction in sensitive cells treated with imatinib, whereas GLUT-1 remained located at the plasma membrane in LAMA84-r and K562-r cells.
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19963135 Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM: UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet. 2010 Jan 1;196(1):45-55.


The cells also display glucose-dependent growth, an elevated rate of lactate efflux, and overexpression of the glucose transporter GLUT1 and of lactate dehydrogenase A (LDHA).
1(0,0,0,1) Details