Protein Information

Name HSCR
Synonyms ABCDS; EDNRB; ET B; ETB; ETRB; Endothelin B receptor; Endothelin B receptor precursor; Endothelin receptor Non selective type…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19853744 Moore SW, Zaahl M: Clinical and genetic differences in total colonic aganglionosis in Hirschsprung's disease. J Pediatr Surg. 2009 Oct;44(10):1899-903.


Although apparently the same condition as Hirschsprung's disease (HSCR), total colonic aganglionosis (TCA) patients (2%-14% congenital aganglionosis) display clinical, histopathologic, and genetic differences that may account for altered clinical presentations.
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19797914 Karram T, Khamaisi M, Bishara B, Ramadan R, Nitecki S, Ben-Izhak O, Meretyk S, Winaver J, Heyman SN, Hoffman A, Abassi Z: Urinary excretion of endothelin receptors ET A and ET B in hypertensive patients and normotensive subjects. Kidney Blood Press Res. 2009;32(4):293-303. Epub 2009 Oct 1.

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18493886 Martucciello G: Hirschsprung's disease, one of the most difficult diagnoses in pediatric surgery: a review of the problems from clinical practice to the bench. Eur J Pediatr Surg. 2008 Jun;18(3):140-9.


PURPOSE: The diagnosis of Hirschsprung's disease (HSCR) should take place early in the neonatal period, because without an effective diagnosis and appropriate treatment, a considerable proportion of infants will go on to develop serious complications such as acute enterocolitis or toxic megacolon.
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19572138 Moore SW: Total colonic aganglionosis and Hirschsprung's disease: shades of the same or different?. Pediatr Surg Int. 2009 Aug;25(8):659-66. Epub 2009 Jul 2.


Total colonic aganglionosis is a relatively uncommon form of Hirschsprung's disease (HSCR) occurring in approximately 2-13% of cases.
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