Protein Information

Name neurotrophic factors
Synonyms ARTN; Artemin; Artemin precursor; EVN; Enovin; NBN; Neublastin; Neuroblastin…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
15597466 Gourion D, Perrin E, Quintin P: [Fluoxetine: an update of its use in major depressive disorder in adults] . Encephale. 2004 Jul-Aug;30(4):392-9.


On the other hand, it has also been postulated that 5-HT is a modulator of several neurophysiological pathways, including dopamine, noradrenaline, but also neurotrophic factors, intra-cytoplasmic phosphorylations and nuclear genes expression.
2(0,0,0,2) Details
12548706 Tabuchi A, Funaji K, Nakatsubo J, Fukuchi M, Tsuchiya T, Tsuda M: Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J Neurosci Res. 2003 Feb 15;71(4):504-15.


Suppression of the apoptosis of CGCs mediated by the Ca (2+) influx or neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and adenylate cyclase activating polypeptide-38 (PACAP-38) attenuated the aconitase inactivation as well as the lactate dehydrogenase (LDH)-release and the decrease in MTT reduction.
1(0,0,0,1) Details
12422559 Bourin M, David DJ, Jolliet P, Gardier A: [Mechanism of action of antidepressants and therapeutic perspectives] . Therapie. 2002 Jul-Aug;57(4):385-96.


Indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various G proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (BDNF).
1(0,0,0,1) Details