| Name | brains |
|---|---|
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12646315 | Miccheli A, Puccetti C, Capuani G, Di Cocco ME, Giardino L, Calza L, Battaglia A, Battistin L, Conti F: [1-13C] entry in neuronal and astrocytic intermediary metabolism of aged rats. Brain Res. 2003 Mar 14;966(1):116-25. Significant increases in lactate levels, as well as in / ratios (Cr/PCr), and a decrease in N-acetyl- (NAA) and levels were observed in aged rat brains as compared to adult animals following administration. |
5(0,0,0,5) | Details |
| 15337301 | Bubber P, Ke ZJ, Gibson GE: Tricarboxylic acid cycle enzymes following thiamine deficiency. . Neurochem Int. 2004 Dec;45(7):1021-8. The -dependent enzymes of the tricarboxylic acid (TCA) cycle are reduced following TD and in the brains of patients that died from multiple neurodegenerative diseases. |
3(0,0,0,3) | Details |
| 19217527 | Mori T, Sun LQ, Kobayashi M, Kiyono Y, Okazawa H, Furukawa T, Kawashima H, Welch MJ, Fujibayashi Y: Preparation and evaluation of ethyl [(18) F] fluoroacetate as a proradiotracer of [(18) F] fluoroacetate for the measurement of glial metabolism by PET. Nucl Med Biol. 2009 Feb;36(2):155-62. In the brain permeability study, the BUI of [(14) C] EFA was 3.8 times higher than that of [1-(14) C] fluoroacetate. [(14) C] EFA was hydrolyzed rapidly in rat brains. |
2(0,0,0,2) | Details |
| 18206986 | Shi Q, Xu H, Kleinman WA, Gibson GE: Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta. 2008 Apr;1782(4):229-38. Epub 2007 Dec 31. Measures in autopsied brains from Alzheimer's Disease (AD) patients reveal a decrease in the activity of alpha-ketoglutarate dehydrogenase complex (KGDHC) and an increase in malate dehydrogenase (MDH) activity. |
1(0,0,0,1) | Details |
| 17607769 | Zielke HR, Zielke CL, Baab PJ: Oxidation of (14) C-labeled compounds perfused by microdialysis in the brains of free-moving rats. J Neurosci Res. 2007 Nov 1;85(14):3145-9. |
1(0,0,0,1) | Details |
| 12527416 | Huang HM, Zhang H, Xu H, Gibson GE: Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular regulation. Biochim Biophys Acta. 2003 Jan 20;1637(1):119-26. A reduction in the activity of the KGDHC occurs in brains and cells of patients with many of these disorders and may underlie the abnormal mitochondrial function. |
1(0,0,0,1) | Details |
| 15852400 | Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE: Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol. 2005 May;57(5):695-703. Brains were from patients with autopsy-confirmed AD and clinical dementia ratings (CDRs) before death. |
1(0,0,0,1) | Details |
| 16488173 | Klein M, Paul R, Angele B, Popp B, Pfister HW, Koedel U: Protein expression pattern in experimental pneumococcal meningitis. . Microbes Infect. 2006 Apr;8(4):974-83. Epub 2006 Jan 18. At different time points before and after antibiotic therapy, the cytokine expression pattern was determined in mouse brains using protein arrays. |
1(0,0,0,1) | Details |
| 16496294 | Singh R: Neuroembryopathic effect of trichloroacetic acid in rats exposed during organogenesis. Birth Defects Res B Dev Reprod Toxicol. 2006 Feb;77(1):47-52. Fetal brains were examined for their external and histological malformation. |
1(0,0,0,1) | Details |
| 12397112 | Jones L, Lopez-Bendito G, Gruss P, Stoykova A, Molnar Z: Pax6 is required for the normal development of the forebrain axonal connections. Development. 2002 Nov;129(21):5041-52. Carbocyanine dye tracing in Pax6 heterozygotes (Pax6 (+/-)) and Pax6 wild-type (Pax6 (+/+)) brains revealed that CFAs and TCAs temporarily arrested their growth at E14.5 at the border of the beta-galactosidase-positive region at the pallial/subpallial boundary (PSPB), before they continued towards their targets. |
1(0,0,0,1) | Details |
| 17054944 | Paskulin R, Jamnik P, Zivin M, Raspor P, Strukelj B: Ibogaine affects brain energy metabolism. . Eur J Pharmacol. 2006 Dec 15;552(1-3):11-4. Epub 2006 Sep 16. The aim of this study was to investigate the effect of ibogaine on protein expression in rat brains. |
1(0,0,0,1) | Details |
| 15664335 | Batifoulier F, Verny MA, Besson C, Demigne C, Remesy C: Determination of and its esters in rat tissues analyzed as thiochromes on a RP-amide C16 column. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):67-72. Analysis of vitamers in tissues of rat submitted to 8 days thiamin deficiency, followed by a 14 days repletion, showed a significant reduction of TPP after 8 days of depletion in liver (-67%), brains (-50%), kidneys (-60%), followed by a complete recovery upon repletion. |
1(0,0,0,1) | Details |