| Name | apical sodium dependent bile acid transporter |
|---|---|
| Synonyms | ASBT; Apical sodium dependent bile acid transporter; IBAT; ISBT; Ileal Na(+)/bile acid cotransporter; Ileal Sodium/Bile Salt Transporter; Ileal sodium dependent bile acid transporter; Ileal sodium/bile acid cotransporter… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15133850 | Kip NS, Lazaridis KN, Masyuk AI, Splinter PL, Huebert RC, LaRusso NF: Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion. World J Gastroenterol. 2004 May 15;10(10):1440-6. Cholangiocytes possess ASBT, an apical sodium-dependent bile acid transporter to take up bile acids, and t-ASBT, a basolateral alternatively spliced and truncated form of ASBT to efflux bile acids. |
7(0,0,0,7) | Details |
| 17675326 | Kalia N, Hardcastle J, Keating C, Grasa L, Keating C, Pelegrin P, Bardhan KD, Grundy D: Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids. Gut. 2008 Jan;57(1):41-9. Epub 2007 Aug 3. Changes in the protein expression of apical sodium-dependent bile acid transporter (ASBT) were also measured. |
4(0,0,0,4) | Details |
| 14563430 | Kida M, Mano Y, Ueno Y, Kobayashi K, Goto J, Ishii M, Shimosegawa T: Vectorial transport of bile acids in immortalized mouse bile duct cells. Hepatol Res. 2003 Oct;27(2):151-157. In ileal epithelial cells, apical sodium-dependent bile acid transporter (ASBT) is responsible for the uptake of bile acids from the lumen. |
4(0,0,0,4) | Details |
| 18311924 | Khantwal CM, Swaan PW: Cytosolic half of transmembrane domain IV of the human bile acid transporter hASBT (SLC10A2) forms part of the substrate translocation pathway. Biochemistry. 2008 Mar 25;47(12):3606-14. Epub 2008 Mar 1. |
2(0,0,0,2) | Details |
| 17690477 | Saeki T, Munetaka Y, Ueda K, Iwami K, Kanamoto R: Effects of substitution for conserved Cys residues in mouse ileal and hepatic Na+-dependent bile acid transporters. Biosci Biotechnol Biochem. 2007 Aug;71(8):1865-72. Epub 2007 Aug 7. Although ileal and hepatic Na (+)-dependent bile acid transporters (SLC10A2 and SLC10A1 respectively) share structural similarities, the mutation of conserved amino acids often has distinct effects on them. |
2(0,0,0,2) | Details |
| 16387497 | Ray A, Banerjee A, Chang C, Khantwal CM, Swaan PW: Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of residues in bile acid binding and transporting proteins. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1473-6. Epub 2006 Jan 4. The purpose of this study was to design bile acid-containing methanethiosulfonate (MTS) agents with appropriate physical attributes to effectively modify the residues present in the human apical sodium-dependent bile acid transporter. The specificity of the synthesized bile acid-MTS conjugate toward native cysteines and putative bile acid interacting domains of hASBT was supported by the effect of 1mM cholyl-MTS, cholylglycyl-MTS, and 3-amino-cholyl-MTS on uptake activity, that displayed a significant decrease in TCA affinity (K (T)=69.9+/-4.5, 69.01+/-6.2, and 63.24+/-0.26 microM and J (max)=35.8+/-0.3, 24.03+/-1.22, 46.49+/-5.01 pmol mg protein min (-1), respectively). |
1(0,0,0,1) | Details |