Protein Information

Name ATPases
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12841626 Malarkodi KP, Balachandar AV, Varalakshmi P: The influence of lipoic acid on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 2003 May;247(1-2):15-22.


This decrease in the activities of ATPases and alkaline phosphatase suggests basolateral and brush-border membrane damage.
2(0,0,0,2) Details
19931487 Chatterjee I, Neumayer D, Herrmann M: Senescence of staphylococci: using functional genomics to unravel the roles of ClpC ATPase during late stationary phase. Int J Med Microbiol. 2010 Feb;300(2-3):130-6. Epub 2009 Nov 20.


More recently, in S. aureus various Clp ATPases have been found to influence global regulator functions resulting in complex phenotypic changes.
2(0,0,0,2) Details
16120273 de Grey AD: A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion. 2001 Aug;1(2):129-39.


The cell's ATP synthesis capacity is thereby diminished, but so is its ATP demand, due to reduced turnover of the Na+/K+-ATPase.
1(0,0,0,1) Details
17390589 Schuhmann T, Vollmar D, Grond S: Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors. J Antibiot. 2007 Jan;60(1):52-60.


The microbial macrolides bafilomycin A1, B, and concanamycin A from Streptomyces spp. are potent and specific inhibitors of V-ATPases.
1(0,0,0,1) Details