| Name | malate dehydrogenase |
|---|---|
| Synonyms | ME3; Malate dehydrogenase; NADP ME; Pyruvic malic carboxylase; Malic enzyme 3; Mitochondrial NADP(+) dependent malic enzyme 3; Malic enzyme 3s; Mitochondrial NADP(+) dependent malic enzyme 3s |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18206986 | Shi Q, Xu H, Kleinman WA, Gibson GE: Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta. 2008 Apr;1782(4):229-38. Epub 2007 Dec 31. Measures in autopsied brains from Alzheimer's Disease (AD) patients reveal a decrease in the activity of alpha-ketoglutarate dehydrogenase complex (KGDHC) and an increase in malate dehydrogenase (MDH) activity. |
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| 18162426 | de Jongh WA, Nielsen J: Enhanced production through gene insertion in Aspergillus niger. Metab Eng. 2008 Mar;10(2):87-96. Epub 2007 Nov 17. Several different genes were inserted individually and in combination, i.e. malate dehydrogenase (mdh2) from Saccharomyces cerevisiae, two truncated, cytosolic targeted, fumarases (Fum1s and FumRs) from S. cerevisiae and Rhizopus oryzae, respectively, and the cytosolic soluble reductase (Frds1) from S. cerevisiae. |
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| 16555951 | Wu JL, Wu QP, Huang JM, Chen R, Cai M, Tan JB: Effects of on physical stamina and activities of enzymes related to the - shuttle in liver of mice. Physiol Res. 2007;56(2):213-20. Epub 2006 Mar 23. The activities of cytosolic and mitochondrial malate dehydrogenase were significantly elevated in the -treated group compared with the control group. |
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| 14996808 | Kromer JO, Sorgenfrei O, Klopprogge K, Heinzle E, Wittmann C: In-depth profiling of -producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol. 2004 Mar;186(6):1769-84. In contrast, cytoplasmic malate dehydrogenase expression increased despite a reduction of the TCA cycle flux, probably related to its contribution to regeneration under conditions of reduced growth. |
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| 18951770 | Bhatt DK, Bano M: Modulation of tricarboxylic acid cycle dehydrogenases during hepatocarcinogenesis induced by hexachlorocyclohexane in mice. Exp Toxicol Pathol. 2009 Jul;61(4):325-32. Epub 2008 Oct 31. The activity of TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) have been studied. |
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| 16143346 | Senthilnathan P, Padmavathi R, Magesh V, Sakthisekaran D: Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. Life Sci. 2006 Jan 25;78(9):1010-4. Epub 2005 Sep 6. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in lung cancer bearing animals were observed. |
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| 18001705 | Veena CK, Josephine A, Preetha SP, Rajesh NG, Varalakshmi P: Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan. Eur J Pharmacol. 2008 Jan 28;579(1-3):330-6. Epub 2007 Oct 16. The tricarboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and respiratory complex enzyme activities were assessed to evaluate mitochondrial function. |
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| 14604472 | Arathi G, Sachdanandam P: Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J Pharm Pharmacol. 2003 Sep;55(9):1283-90. The activities of mitochondrial enzymes isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH-dehydrogenase and cytochrome C oxidase were significantly lowered in mammary carcinoma-bearing rats when compared with control rats. |
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| 18336823 | Fleige T, Pfaff N, Gross U, Bohne W: Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii. Int J Parasitol. 2008 Aug;38(10):1121-32. Epub 2008 Feb 13. Based on the expression and localisation of epitope-tagged fusion proteins, we show that all analysed TCA cycle enzymes are localised in the mitochondrion, including both isoforms of malate dehydrogenase. |
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| 16209543 | Wang Y, Wu SL, Hancock WS, Trala R, Kessler M, Taylor AH, Patel PS, Aon JC: Proteomic profiling of Escherichia coli proteins under high cell density fed-batch cultivation with overexpression of phosphogluconolactonase. Biotechnol Prog. 2005 Sep-Oct;21(5):1401-11. During the time course of samples collected during the rapid growth achieved under batch and fed-batch conditions, both the control and recombinant E. coli strains showed up-regulation of proteins participating in the tricarboxylic acid (TCA) cycle, particularly acetyl-CoA synthetase (AcCoAS), malate dehydrogenase (MDH), and synthetase (SuccCoAS). |
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| 19053364 | Schiavon M, Ertani A, Nardi S: Effects of an alfalfa protein hydrolysate on the gene expression and activity of enzymes of the tricarboxylic acid (TCA) cycle and nitrogen metabolism in Zea mays L. J Agric Food Chem. 2008 Dec 24;56(24):11800-8. The activity of a number of enzymes involved in carbon (C) metabolism (malate dehydrogenase, MDH; isocitrate dehydrogenase, IDH; citrate synthase, CS) and N reduction and assimilation reductase, NR; reductase, NiR; glutamine synthetase, GS; synthase, GOGAT; aspartate aminotransferase, AspAT) was significantly induced by EM supply to plants, and the transcription pattern of MDH, IDH, CS, and NR strongly correlated with data of enzyme activity. |
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| 15852400 | Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE: Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol. 2005 May;57(5):695-703. Activities of succinate dehydrogenase (complex II) (+44%) and malate dehydrogenase (+54%) were increased (p < 0.01). |
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| 16495757 | Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P: Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity. J Cardiovasc Pharmacol. 2006 Feb;47(2):205-10. A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase were noted in CP-treated rats. |
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| 12631716 | McCammon MT, Epstein CB, Przybyla-Zawislak B, McAlister-Henn L, Butow RA: Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell. 2003 Mar;14(3):958-72. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. |
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| 12138751 | Il'chenko AP, Cherniavskaia OG, Shishkanova NV, Finogenova TV: [Metabolism of Yarrowia lipolytica grown on under conditions promoting the production of alpha-ketoglutaric and citric acids: a comparative study of the central metabolism enzymes]. Mikrobiologiia. 2002 May-Jun;71(3):316-22. A comparative study of the enzymes of the tricarboxylic acid (TCA) and cycles in the mutant Yarrowia lipolytica strain N1 capable of producing alpha-ketoglutaric acid (KGA) and showed that almost all enzymes of the TCA cycle are more active under conditions promoting the production of KGA. The activities of malate dehydrogenase, aconitase, -dependent isocitrate dehydrogenase, and fumarase were higher in cells producing KGA than in cells producing |
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| 16758861 | Fedorov DV, Podkopaeva DA, Miroshnichenko ML, Bonch-Osmolovskaia EA, Lebedinskii AV, Grabovich MIu: [Investigation of the catabolism of and peptides in the new anaerobic thermophilic bacterium Caldithrix abyssi]. Mikrobiologiia. 2006 Mar-Apr;75(2):154-9. The activity of reductase (0.14 micromol/(min mg protein)), malate dehydrogenase (0.17 micromol/(min mg protein)), and fumarate hydratase (1.2 micromol/(min mg protein)), as well as the presence of cytochrome b, points to the formation of via the methyl- pathway. |
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| 17054944 | Paskulin R, Jamnik P, Zivin M, Raspor P, Strukelj B: Ibogaine affects brain energy metabolism. . Eur J Pharmacol. 2006 Dec 15;552(1-3):11-4. Epub 2006 Sep 16. Enzymes of glycolysis and tricarboxylic acid (TCA) cycle namely glyceraldehyde-3-phosphate dehydrogenase, aldolase A, kinase and malate dehydrogenase were induced. |
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| 17349985 | Arulkumaran S, Ramprasath VR, Shanthi P, Sachdanandam P: Alteration of DMBA-induced oxidative stress by additive action of a modified indigenous preparation--Kalpaamruthaa. Chem Biol Interact. 2007 Apr 25;167(2):99-106. Epub 2007 Feb 4. DMBA-treated rats also showed decline in the activities of mitochondrial enzymes such as succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase. |
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| 16085348 | Mythili Y, Sudharsan PT, Varalakshmi P: ameliorates cyclophosphamide induced cardiac mitochondrial injury. Toxicology. 2005 Nov 5;215(1-2):108-14. Epub 2005 Aug 8. A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase was noted in CP treated rats. |
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| 14526533 | Pirog TP, Kuz'minskaia IuV: [Central metabolism in Acinetobacter sp. grown on . Mikrobiologiia. 2003 Jul-Aug;72(4):459-65. The addition of the C4-dicarboxylic acid to the -containing growth medium led to a 1.5- to 2-fold increase in the activity of enzymes of the cycle, as well as of fumarate hydratase, malate dehydrogenase, PEP synthase, and PEP carboxykinase (the activity of the latter enzyme increased by more than 7.5 times). |
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| 15098932 | Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JC: Differential lowering by treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with -induced cell death. Neurochem Res. 2004 Apr;29(4):709-17. In parallel with the Mn-induced, dose-dependent decrease in cell survival, treatment of these cells with 0.01 to 4.0 mM MnCl2 for 48 h also induced dose-related decreases in their activities of hexokinase, kinase, lactate dehydrogenase, citrate synthase, and malate dehydrogenase. |
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| 15158257 | Peng L, Arauzo-Bravo MJ, Shimizu K: Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements. FEMS Microbiol Lett. 2004 Jun 1;235(1):17-23. Some TCA cycle enzymes such as citrate synthase, aconitase and malate dehydrogenase were also upregulated, but enzymes of glycolysis and the pentose phosphate pathway were downregulated. |
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| 20199583 | Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T: attenuates mitochondrial dysfunction during benzo (a) pyrene-induced lung carcinogenesis in mice. Fundam Clin Pharmacol. 2010 Feb 22. B (a) P (50 mg/kg body weight)-induced mitochondrial abnormalities was evident from alterations in mitochondrial lipid peroxides, antioxidant status (superoxide dismutase, catalase, peroxidase, glutathione reductase, glutathione-S-transferase, and major tricarboxylic acid (TCA) cycle enzyme activities (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase), electron transport chain (ETC) complexes activities and levels. |
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| 20222442 | Zhang D, Liu L, Du G, Chen J: [Physiological function of alpha-ketoglutarate dehydrogenase complex in Torulopsis glabrata]. Wei Sheng Wu Xue Bao. 2009 Dec 4;49(12):1584-9. But the specific activities of pyruvate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase increased by 58.1%, 33.3% and 32.5%, respectively; (c) the intracellular concentration of was reduced by 49.9%, while the intracellular concentration of and alpha-ketoglutarate was higher 172.7%, 66.1% and 41.1% than the corresponding values of the control; (d) The content of -family amino acid was 29.3% lower while the level of -family amino acid and -family amino acid were 34.7% and 26.8% higher than that of control. |
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| 16786185 | Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T: Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007 Jan;294(1-2):55-63. Epub 2006 Jun 20. Adriamycin (2.5 mg/kg body wt., i.p.) induced mitochondrial damage in rats was assessed in terms of decreased activities (p <0.05) of cardiac marker enzymes (lactate dehydrogenase, phosphokinase, amino transferases), TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase, respiratory marker enzymes (NADH-dehydrogenase, cytochrome-C-oxidase), mitochondrial antioxidant enzymes (GPx, GSH, SOD,CAT) and increased (p <0.05) level of lipid peroxidation. |
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| 20167786 | Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL: Regulation of cellular metabolism by protein acetylation. . Science. 2010 Feb 19;327(5968):1000-4. Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis. |
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| 12841626 | Malarkodi KP, Balachandar AV, Varalakshmi P: The influence of on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 2003 May;247(1-2):15-22. Decreased activities of the TCA cycle enzymes isocitrate dehydrogenase, succinate dehydrogenase and malate dehydrogenase, suggest a loss in mitochondrial function and integrity. |
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| 15337301 | Bubber P, Ke ZJ, Gibson GE: Tricarboxylic acid cycle enzymes following thiamine deficiency. . Neurochem Int. 2004 Dec;45(7):1021-8. Non--dependent enzymes such as succinate dehydrogenase (SDH), thiokinase (STH) and malate dehydrogenase (MDH) were altered as much or more than -dependent enzymes such as the alpha-ketoglutarate dehydrogenase complex (KGDHC) (-21.5%) and PDHC (-10.5%). |
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| 15565635 | Lo AS, Liew CT, Ngai SM, Tsui SK, Fung KP, Lee CY, Waye MM: Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1). J Cell Biochem. 2005 Mar 1;94(4):763-73. Human cyotsolic malate dehydrogenase (MDH1) is important in transporting equivalents across the mitochondrial membrane, controlling tricarboxylic acid (TCA) cycle pool size and providing contractile function. |
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| 18569708 | Rajendran P, Ekambaram G, Sakthisekaran D: Effect of mangiferin on benzo (a) pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat Prod Res. 2008 May 20;22(8):672-80. Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed. |
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| 20136350 | Muralikrishnan G, Amanullah S, Basha MI, Dinda AK, Shakeel F: Modulating effect of Withania somnifera on TCA cycle enzymes and electron transport chain in azoxymethane-induced colon cancer in mice. Immunopharmacol Immunotoxicol. 2010 Feb 5. After the experimental period, the animals were killed and analyzed for TCA cycle key enzymes, such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and alpha-keto dehydrogenase (alpha-KGDH). |
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| 12244711 | Stepanova IIu, Eprintsev AT, Falaleeva MI, Parfenova NV, Grabovich MIu, Patritskaia VIu, Dubinina GA: [Dependence of the structure of malate dehydrogenase on the type of metabolism in fresh water filamentous colorless bacteria of the Beggiatoa species]. Mikrobiologiia. 2002 Jul-Aug;71(4):445-51. |
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| 15521166 | Eprintsev AT, Falaleeva MI, Grabovich MIu, Parfenova NV, Kashirskaia NN, Dubinina GA: [Role of malate dehydrogenase isoforms in the regulation of anabolic and catabolic processes in the colorless bacterium Beggiatoa leptomitiformis D-402]. Mikrobiologiia. 2004 Jul-Aug;73(4):437-42. |
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| 18825970 | Mysiakina IS, Funtikova NS: [Activity of NAD-dependent isocitrate dehydrogenase, lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of supply]. Mikrobiologiia. 2008 Jul-Aug;77(4):453-9. |
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| 19340598 | Kumar V, Sahu NP, Pal AK, Kumar S, Sinha AK, Ranjan J, Baruah K: Modulation of key enzymes of glycolysis, gluconeogenesis, amino acid catabolism, and TCA cycle of the tropical freshwater fish Labeo rohita fed gelatinized and non-gelatinized starch diet. Fish Physiol Biochem. 2009 Apr 2. A 60-day experiment was conducted to study the effect of dietary gelatinized (G) and non-gelatinized (NG) starch on the key metabolic enzymes of glycolysis (hexokinase, glucokinase, kinase, and lactate dehydrogenase), gluconeogenesis (glucose-6 phosphatase and -1,6 bisphosphatase), protein metabolism amino transferase and amino transferase), and TCA cycle (malate dehydrogenase) in Labeo rohita juveniles. |
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| 15597737 | Dymov SI, Meek DJ, Steven B, Driscoll BT: Insertion of transposon Tn5tac1 in the Sinorhizobium meliloti malate dehydrogenase (mdh) gene results in conditional polar effects on downstream TCA cycle genes. Mol Plant Microbe Interact. 2004 Dec;17(12):1318-27. |
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| 18094529 | Choi YJ, Uhm SJ, Song SJ, Song H, Park JK, Kim T, Park C, Kim JH: Cytochrome c upregulation during capacitation and spontaneous acrosome reaction determines the fate of pig sperm cells: linking proteome analysis. J Reprod Dev. 2008 Feb;54(1):68-83. Epub 2007 Dec 18. After induction of capacitation in vitro, the well-established markers of the capacitation (lactadherin P47, acrosomal protein SP-10 precursor, prohibitin, proteasomes, DJ-1 protein and arylsulfatase-A) and TCA cycle proteins (isocitrate dehydrogenase, malate dehydrogenase and pyruvate dehydrogenase) were identified. |
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| 17273855 | Veit A, Polen T, Wendisch VF: Global gene expression analysis of overflow metabolism in Escherichia coli and reduction of aerobic formation. Appl Microbiol Biotechnol. 2007 Feb;74(2):406-21. Epub 2006 Nov 25. A correlation analysis identified that expression of ten genes (sdhCDAB, sucB, sucC, acnB, lpdA, fumC and mdh) encoding the TCA cycle enzymes succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, synthetase, aconitase, fumarase and malate dehydrogenase, respectively, and of the acs-yjcH-actP operon for utilization correlated negatively with formation. |
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| 16413626 | Mohankumar K, Ramasamy P: Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. Virus Res. 2006 Jun;118(1-2):130-5. Epub 2006 Jan 18. The activities of membrane bound phosphatases (Na (+) K (+) ATPase, Ca (2+) ATPase, Mg (2+) ATPase and Total ATPase), transaminases transaminase (ALT) and transaminase (AST)) and mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), alpha-ketoglutarate dehydrogenase (KGDH), NADH dehydrogenase, cytochrome C oxidase) in WSSV-infected tissues (hemolymph, hepatopancreas, gills and muscle) of Fenneropenaeus indicus were determined at intervals after WSSV infection (0, 24, 48, 72 and after 72 h (moribund)). |
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| 16839657 | Chan M, Tan DS, Wong SH, Sim TS: A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization. Biochimie. 2006 Oct;88(10):1367-75. Epub 2006 Jun 22. These eukaryotic cells serve as an in vitro living system for studying the cellular destinations of four mitochondrial-targeted TCA cycle proteins (citrate synthase, CS; isocitrate dehydrogenase, ICDH; branched chain alpha-keto-acid dehydrogenase E1alpha subunit, BCKDH; succinate dehydrogenase flavoprotein-subunit, SDH), two nuclear-targeted proteins (histone deacetylase, HDAC; RNA polymerase, RPOL), two apicoplast-targeted proteins kinase 2, PK2; dehydrogenase, GDH), and two cytoplasmic resident proteins (malate dehydrogenase, MDH; glycerol kinase, GK). |
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| 15881660 | Selvendiran K, Thirunavukkarasu C, Singh JP, Padmavathi R, Sakthisekaran D: Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and -metabolizing enzymes in benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice. Mol Cell Biochem. 2005 Mar;271(1-2):101-6. Lung cancer bearing mice showed a significant decrease in the activities of mitochondrial enzymes-isocitrate dehydrogenase (ICDH), -ketoglutarate dehydrogenase (KDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and significantly increased -Cytochorome reductase -C reductase), cytochrome P450 (cyt-p450) and cytochrome b5 (cyt-b5). |
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| 17574827 | Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan R: Protective effect of dietary supplementation on mitochondrial function in liver of aged rats. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):349-55. Epub 2007 Jun 15. The dietary supplementation of 2% significantly minimized aging associated alterations in mitochondrial energy status by maintaining the activities of TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase) and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at higher level in the liver mitochondria of aged rats compared with unsupplemented controls. |
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| 15919137 | Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C: Efficacy of levo and in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794-800. METHODS: In the present study we have evaluated the efficacy of a mitochondrial metabolite and a potent antioxidant on the activities of the tri carboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase, Isocitrate dehydrogenase and electron transport complex I-IV in young and aged heart mitochondria. |
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