| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20139904 | Cheng LM, Jiang JG, Sun ZY, Chen C, Dackor RT, Zeldin DC, Wang DW: The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells. Acta Pharmacol Sin. 2010 Feb;31(2):211-8. RESULTS: Both the addition of 14,15-EET and the transfection of cells with CYP102 F87V markedly increased the phosphorylation of the residues of EGF-R and ERK1/2, an effect that was blocked by a selective EGF-R kinase inhibitor (tyrphostin AG1478), a broad-spectrum metalloproteinase inhibitor (1,10-phenanthroline), and an inhibitor of HB-EGF release (CRM197) in Tca-8113 cells. |
33(0,1,1,3) | Details |
| 19448409 | Jiang JG, Shen GF, Chen C, Fu XN, Wang DW: Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. Ai Zheng. 2009 Jan;28(1):14-9. Epub 2009 Jan 5. METHODS: The effects of recombinant adeno-associated virus (rAAV) mediated cytochrome P450 2J2 (CYP2J2), cytochrome P450 F87V (CYPF87V) and anti-CYP2J2 on proliferation of Tca-8113, A549, Ncl-H446 and HepG2 cells were measured using MTT and flow cytometry. Expressions of phosphorylated epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK) 1/2 and Akt before and after transfection were detected by western blot. |
3(0,0,0,3) | Details |
| 16317705 | Dent P, Fang Y, Gupta S, Studer E, Mitchell C, Spiegel S, Hylemon PB: Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes. Hepatology. 2005 Dec;42(6):1291-9. |
2(0,0,0,2) | Details |
| 19000441 | Shen GF, Jiang JG, Fu XN, Wang DW: [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells]. Ai Zheng. 2008 Nov;27(11):1130-6. METHODS: Four tumor cell lines, Tca-8113, A549, Ncl-H446 and HepG2, were treated with different concentrations of EETs (8,9-EET, 11,12-EET and 14,15-EET) for 12, 24, 48 and 72 h, respectively. Expressions of the total protein and phosphorylated ERK1/2 and Akt were determined by Western blot. |
1(0,0,0,1) | Details |