Protein Information

Name PARP 1
Synonyms DDF 1; PARP 1; DDF1; PARP 7; PARP7; TCDD inducible poly ADP ribose polymerase; TCDD inducible poly(ADP ribose) polymerase; TIPARP…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16736046 Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L: Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab. 2007 Feb;27(2):304-15. Epub 2006 May 24.

3(0,0,0,3) Details
15377881 Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L: Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr. 2004 Aug;36(4):415-9.

It appears possible to use brain slices to quantitatively study PARP-related, NAD-associated energy failure, and rescue with TCA metabolites.
1(0,0,0,1) Details