Protein Information

Name GTPase
Synonyms RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16581157 Bierczynska-Krzysik A, Bonar E, Drabik A, Noga M, Suder P, Dylag T, Dubin A, Kotlinska J, Silberring J: Rat brain proteome in morphine dependence. Neurochem Int. 2006 Sep;49(4):401-6. Epub 2006 Apr 3.

Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem mass spectrometry, allowed for identification of eleven potential dependence markers, mainly cytoplasmic and mitochondrial enzymes, e.g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families.
81(1,1,1,1) Details
16352658 Nishimura Y, Yonemura S: Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J Cell Sci. 2006 Jan 1;119(Pt 1):104-14. Epub 2005 Dec 13.


Although the small GTPase RhoA is known to regulate the progression, probably by controlling actin filament assembly and enhancing actomyosin interaction, any involvement of RhoA in division plane determination is unknown.
1(0,0,0,1) Details
19635791 Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG: Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem. 2009 Sep 25;284(39):26578-90. Epub 2009 Jul 27.


Here we have investigated whether the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) is the GTPase linking hydrolysis of mtGTP made by succinyl-CoA synthetase (SCS-GTP) to an anaplerotic pathway producing phosphoenolpyruvate (PEP).
1(0,0,0,1) Details