Protein Information

Name TCA 3
Synonyms CCL 1; CCL1; I 309; I309; Inflammatory cytokine I 309; P500; SCYA 1; SCYA1…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
17164723 Xie JF, Wang G, Debonera F, Han R, Dorf ME, Hancock W, Olthoff KM: Selective neutralization of the chemokine TCA3 reduces the increased injury of partial versus whole liver transplants induced by cold preservation. Transplantation. 2006 Dec 15;82(11):1501-9.

3(0,0,0,3) Details
19743814 Zulkefeli M, Sogon T, Takeda K, Kimura E, Aoki S: Design and synthesis of a stable supramolecular trigonal prism formed by the self-assembly of a linear tetrakis (Zn2+-cyclen) complex and trianionic trithiocyanuric acid in aqueous solution and its complexation with DNA (cyclen = 1,4,7,10-tetraazacyclododecane). Inorg Chem. 2009 Oct 5;48(19):9567-78.


A new supramolecular complex, {(Zn (4) L (4))(3)-(TCA (3-))(4)}(12+), was designed and synthesized by the 3:4 self-assembly of a linear tetrakis (Zn (2+)-cyclen) complex (Zn (4) L (4))(8+) and trianionic trithiocyanurate (TCA (3-)) in aqueous solution (cyclen = 1,4,7,10-tetraazacyclododecane).
2(0,0,0,2) Details
12510387 Aoki S: [Supramolecular chemistry of multinuclear zinc (II) complexes in aqueous solution]. Yakugaku Zasshi. 2002 Dec;122(12):1095-108.


TCA acted as a tridentate donor for three Zn3L1 at neutral pH to yield a similar type of 4:4 self-assembling supercomplex, in which the deprotonated TCA3- in an aromatic 1,3,5-triazine binds to Zn3L1 through Zn (2+)-S- (exocyclic) coordination bonds, and thus the 4:4 assembly is a chiral twisted cuboctahedron.
2(0,0,0,2) Details
12828562 Glabinski AR, Bielecki B, Ransohoff RM: Chemokine upregulation follows cytokine expression in chronic relapsing experimental autoimmune encephalomyelitis. Scand J Immunol. 2003 Jul;58(1):81-8.


Phasic upregulation of gene expression for chemokines T-cell activation gene 3 (TCA-3)/CCL1, monocyte chemoattractant protein-1 (MCP-1)/CCL2, macrophage inflammatory protein-1 alpha (MIP-1alpha)/CCL3, MIP-1beta/CCL4, regulated on activation normal T cell expressed and secreted (RANTES)/CCL5 and MIP-2/CXCL2-3 as well as cytokines tumour necrosis factor-alpha (TNF-alpha), -beta, LT-beta, interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) in the CNS was observed during attacks of ChREAE.
1(0,0,0,1) Details
16488173 Klein M, Paul R, Angele B, Popp B, Pfister HW, Koedel U: Protein expression pattern in experimental pneumococcal meningitis. . Microbes Infect. 2006 Apr;8(4):974-83. Epub 2006 Jan 18.


During later stages, an induction of T-cell activation-3 (TCA-3/CCL1), platelet factor-4 (PF-4/CXCL4) and stromal derived factor-1alpha (SDF-1alpha/CXCL13), and IL-4 was observed.
1(0,0,0,1) Details