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Zulkefeli M, Sogon T, Takeda K, Kimura E, Aoki S: Design and synthesis of a stable supramolecular trigonal prism formed by the self-assembly of a linear tetrakis (Zn2+-cyclen) complex and trianionic trithiocyanuric acid in aqueous solution and its complexation with DNA (cyclen = 1,4,7,10-tetraazacyclododecane). Inorg Chem. 2009 Oct 5;48(19):9567-78.
A new supramolecular complex, {(Zn (4) L (4))(3)-(TCA (3-))(4)}(12+), was designed and synthesized by the 3:4 self-assembly of a linear tetrakis (Zn (2+)-cyclen) complex (Zn (4) L (4))(8+) and trianionic trithiocyanurate (TCA (3-)) in aqueous solution (cyclen = 1,4,7,10-tetraazacyclododecane). The {(Zn (4) L (4))(3)-(TCA (3-))(4)}(12+) complex, which should have a trigonal prism configuration, was found to be very stable in aqueous solution at neutral pH and 25 degrees C, as evidenced by (1) H NMR titration, potentiometric pH and UV titrations, and MS measurements. The complex does not dissociate into the starting building blocks in the presence of Zn (2+)-binding anions such as phosphates and double-stranded DNA. The results of the competitive binding assays with ethidium bromide and calf-thymus DNA, thermal melting experiments, gel mobility shift assays, and dynamic light-scattering data strongly indicated that the trigonal prism functions as a polycationic template to induce the aggregation of double-stranded DNA. |
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