Protein Information

Name mitogen activated protein kinase (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19298531 Chen DD, Dong YG, Liu D, He JG: Epigallocatechin-3-gallate attenuates cardiac hypertrophy partly via MAPKs signals in hypertensive rats. Clin Exp Pharmacol Physiol. 2009 Mar 2.


In the present study, we tested the hypothesis that EGCG attenuates transaortic abdominal aortic constriction (TAC)-induced ventricular hypertrophy via regulating mitogen-activated protein kinases (MAPK) signal pathways in hypertensive rats. 3.
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19000441 Shen GF, Jiang JG, Fu XN, Wang DW: [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells]. Ai Zheng. 2008 Nov;27(11):1130-6.

METHODS: Four tumor cell lines, Tca-8113, A549, Ncl-H446 and HepG2, were treated with different concentrations of EETs (8,9-EET, 11,12-EET and 14,15-EET) for 12, 24, 48 and 72 h, respectively.
Signal transduction inhibitors of PI3K (LY294002), MAPKK (PD98059), MAPK (apigenin) and PKC (H7) were used to block EETs-induced cell proliferation.
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17590509 Chung EY, Shin SY, Lee YH: Amitriptyline induces early growth response-1 gene expression via ERK and JNK mitogen-activated protein kinase pathways in rat C6 glial cells. Neurosci Lett. 2007 Jul 5;422(1):43-8. Epub 2007 Jun 7.

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16055945 Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M, Weizman A: Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci. 2005;27(1):29-42.


In addition, the involvement of MAPK genes, c-Jun, and ERK was determined.
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17594473 Chiu KP, Ariyaratne P, Xu H, Tan A, Ng P, Liu ET, Ruan Y, Wei CL, Sung WK: Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes. BMC Cancer. 2007 Jun 26;7:109.


Upregulation of cell cycle progression, MAPK, and PI3K/Akt pathways were more limited to certain region (s) of the pathway.
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15060153 Lawrence CL, Botting CH, Antrobus R, Coote PJ: Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol. 2004 Apr;24(8):3307-23.


Screening the Saccharomyces cerevisiae disruptome, profiling transcripts, and determining changes in protein expression have identified an important new role for the high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathway in the regulation of adaptation to citric acid stress.
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18383346 Gavillet M, Allaman I, Magistretti PJ: Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia. 2008 Jul;56(9):975-89.


Finally, the effects of cytokines on glucose utilization appear to involve multiple signaling cascades including the phosphoinositide 3-kinase and mitogen-activated protein kinases.
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18491380 Motoki T, Sugiura Y, Matsumoto Y, Tsuji T, Kubota S, Takigawa M, Gohda E: Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation. J Cell Biochem. 2008 Jul 1;104(4):1465-76.

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