Protein Information

Name multidrug resistance associated protein 2
Synonyms ABC30; ABCC 2; ABCC2; ATP binding cassette sub family C member 2; CMOAT; CMOAT 1; CMOAT1; CMRP…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
15280219 Takada T, Weiss HM, Kretz O, Gross G, Sugiyama Y: Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug Metab Dispos. 2004 Nov;32(11):1272-8. Epub 2004 Jul 27.


Here the transport properties of [14C] PKI166 and its main metabolite [14C] ACU154, an O-glucuronide, were analyzed using 1) Madin-Darby canine kidney II (MDCKII) cells stably transfected with human multidrug resistance-associated protein 2 (MRP2) and/or human organic anion-transporting peptide 2 (OATP2) and 2) liver canalicular membrane vesicles (CMVs) prepared from Wistar and mrp2-deficient TR- rats.		 5(0,0,0,5) Details
15901796 Hirano M, Maeda K, Hayashi H, Kusuhara H, Sugiyama Y: Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.


Cumulative studies have shown that pravastatin is taken up into hepatocytes by the organic anion transporting polypeptide family transporters and excreted into the bile as an intact form by multidrug resistance-associated protein 2 (MRP2).		 1(0,0,0,1) Details