Protein Information

Name retinoid X receptor alpha
Synonyms NR2B1; RXR alpha; RXRA; RXRalpha; Retinoic acid receptor RXR alpha; Retinoid X receptor alpha; RXR alphas; RXRalphas…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16258897 Lengqvist J, Mata de Urquiza A, Perlmann T, Sjovall J, Griffiths WJ: Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. J Mass Spectrom. 2005 Nov;40(11):1448-61.

5(0,0,0,5) Details
19074998 Toriyabe T, Nagata K, Takada T, Aratsu Y, Matsubara T, Yoshinari K, Yamazoe Y: Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics. Mol Pharmacol. 2009 Mar;75(3):677-84. Epub 2008 Dec 15.


Pregnane X receptor (PXR) has been shown to form a heterodimer with retinoid X receptor alpha (RXRalpha) and to bind to the distal nuclear receptor-binding element 1 and an everted repeat separated by six nucleotides in the proximal promoter of the CYP3A4 gene.
2(0,0,0,2) Details