Protein Information

Name chemokine receptors (protein family or complex)
Synonyms chemokine receptor; chemokine receptors

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16274458 Renninger ML, Seymour R, Lillard JW Jr, Sundberg JP, HogenEsch H: Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice. Exp Dermatol. 2005 Dec;14(12):906-13.


RNA isolated from the skin of mutant and littermate control mice revealed a significant increase in Ccl1 (TCA-3), Ccl2 (MCP-1), Ccl11 (eotaxin), Ccl17 (TARC), Cxcl10 (IP-10), and the chemokine receptor Ccr3.
2(0,0,0,2) Details
12496446 Chung CD, Kuo F, Kumer J, Motani AS, Lawrence CE, Henderson WR Jr, Venkataraman C: CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. J Immunol. 2003 Jan 1;170(1):581-7.


Chemokine receptors play an important role in the trafficking of various immune cell types to sites of inflammation.
2(0,0,0,2) Details
17164723 Xie JF, Wang G, Debonera F, Han R, Dorf ME, Hancock W, Olthoff KM: Selective neutralization of the chemokine TCA3 reduces the increased injury of partial versus whole liver transplants induced by cold preservation. Transplantation. 2006 Dec 15;82(11):1501-9.


Quantitative analysis showed that compared with expression in whole grafts harvested after the same period of cold ischemia, partial grafts had eightfold more T-cell activation gene (TCA)-3 (CCL1) chemokine messenger RNA (mRNA) expression (P <0.01) and sixfold more inducible protein (IP)-10 chemokine (CCL10) mRNA expression (P <0.01), as well as increased expression of the chemokine receptors CCR8 (receptor for TCA3) and CXCR3 (receptor for IP-10; P <0.01).
1(0,0,0,1) Details