| Name | PI3K |
|---|---|
| Synonyms | GRB 1; PI3K; GRB1; PI3 kinase p85 subunit alpha; Phosphatidyl inositol 3 kinase associated p85 alpha; Phosphatidylinositol 3 kinase regulatory subunit alpha; PtdIns 3 kinase p85 alpha… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19000441 | Shen GF, Jiang JG, Fu XN, Wang DW: [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells]. Ai Zheng. 2008 Nov;27(11):1130-6. METHODS: Four tumor cell lines, Tca-8113, A549, Ncl-H446 and HepG2, were treated with different concentrations of EETs (8,9-EET, 11,12-EET and 14,15-EET) for 12, 24, 48 and 72 h, respectively. Signal transduction inhibitors of PI3K (LY294002), MAPKK (PD98059), MAPK and PKC (H7) were used to block EETs-induced cell proliferation. |
3(0,0,0,3) | Details |
| 19448409 | Jiang JG, Shen GF, Chen C, Fu XN, Wang DW: Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. Ai Zheng. 2009 Jan;28(1):14-9. Epub 2009 Jan 5. METHODS: The effects of recombinant adeno-associated virus (rAAV) mediated cytochrome P450 2J2 (CYP2J2), cytochrome P450 F87V (CYPF87V) and anti-CYP2J2 on proliferation of Tca-8113, A549, Ncl-H446 and HepG2 cells were measured using MTT and flow cytometry. Moreover, CYP epoxgenases remarkably enhanced phosphorylation of EGFR, ERK1/2 and Akt, and upregulated total PI3K by 2-, 2.3-, 2.4- and 1.9-fold in the four cell lines, while rAAV-antiCYP2J2 exerted an inhibition effect. |
2(0,0,0,2) | Details |
| 17594473 | Chiu KP, Ariyaratne P, Xu H, Tan A, Ng P, Liu ET, Ruan Y, Wei CL, Sung WK: Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes. BMC Cancer. 2007 Jun 26;7:109. Upregulation of cell cycle progression, MAPK, and PI3K/Akt pathways were more limited to certain region (s) of the pathway. |
1(0,0,0,1) | Details |
| 19033189 | Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to addiction. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. Epub 2008 Nov 24. Investigations of phosphoinositol 3-kinase (PI3K) and its downstream effector AKT have confirmed that these oncogenes play a direct role in stimulating uptake and metabolism, rendering the transformed cell addicted to for the maintenance of survival. |
1(0,0,0,1) | Details |
| 16390326 | Fernandez-Veledo S, Huber-Ruano I, Aymerich I, Duflot S, Casado FJ, Pastor-Anglada M: Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Biochem J. 2006 Apr 15;395(2):337-44. The induction of CNT2 translocation, triggered by TCA, was inhibited by wortmannin, dibutyryl-AMPc, PD98059 and colchicine, thus suggesting the involvement of the PI3K/ERK (phosphoinositide 3-kinase/extracellular-signal related kinase) pathway in microtubule-dependent activation of recombinant CNT2. |
1(0,0,0,1) | Details |