Protein Information

Name interleukin 1beta
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12954240 Chowdhury TT, Bader DL, Lee DA: Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage. 2003 Sep;11(9):688-96.

6(0,0,0,6) Details
12609461 Dredge K, Connor TJ, Kelly JP, Leonard BE: Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats. Int J Immunopharmacol. 1999 Oct;21(10):663-73.

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16351573 Guo H, Gao C, Mi Z, Wai PY, Kuo PC: Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochem J. 2006 Mar 1;394(Pt 2):379-87.


In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG (G/T) TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA.
1(0,0,0,1) Details
17724602 Yonei N, Kanazawa N, Ohtani T, Furukawa F, Yamamoto Y: Induction of PDGF-B in TCA-treated epidermal keratinocytes. . Arch Dermatol Res. 2007 Nov;299(9):433-40. Epub 2007 Aug 28.


Expressions of inflammatory cytokines such as interleukin (IL)-1 and IL-10 were also induced.
1(0,0,0,1) Details
18383346 Gavillet M, Allaman I, Magistretti PJ: Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia. 2008 Jul;56(9):975-89.


In our study, we report that a combination of IL-1beta and TNFalpha exerts a synergistic effect on glucose utilization and markedly modifies the metabolic phenotype of astrocytes.
1(0,0,0,1) Details
16488173 Klein M, Paul R, Angele B, Popp B, Pfister HW, Koedel U: Protein expression pattern in experimental pneumococcal meningitis. . Microbes Infect. 2006 Apr;8(4):974-83. Epub 2006 Jan 18.


Underlining the power of this method, the meningitis-relevant cytokines interleukin-1beta (IL-1beta), IL-6, KC, macrophage inflammatory protein-2 (MIP-2), and monocyte chemoattractant protein-1 (MCP-1/CCL2) were markedly elevated in infected animals.
1(0,0,0,1) Details