Protein Information

Name macrophage inflammatory protein 1 alpha
Synonyms CCL 3; CCL3; G0/G1 switch regulatory protein 19 1; G0S19 1; G0S19 1 protein; LD78 alpha; LD78ALPHA; MIP 1 alpha Tonsillar lymphocyte LD78 alpha protein…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12738268 Weissflog L, Kruger G, Elansky N, Putz E, Pfennigsdorff A, Seyfarth KU, Nuchter M, Lange C, Kotte K: Input of trichloroacetic acid into the vegetation of various climate zones--measurements on several continents. Chemosphere. 2003 Jul;52(2):443-9.


Trichloroacetic acid (TCA, CCl (3) COOH) is a phytotoxic chemical.
2(0,0,0,2) Details
17380379 Beretti F, Cenacchi V, Portolani M, Ardizzoni A, Blasi E, Cermelli C: A transmissible cytotoxic activity isolated from a patient with brain ischemia causes microglial cell activation and dysfunction. Cell Mol Neurobiol. 2007 Jun;27(4):517-28. Epub 2007 Mar 23.


Moreover, TCA-treated cells produced amounts of macrophage inflammatory protein 1-alpha, tumor necrosis factor-alpha, and nitric oxide significantly higher than mock-treated cells.
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15158031 Dickey CA, Heal KV, Stidson RT, Koren R, Schroder P, Cape JN, Heal MR: Trichloroacetic acid cycling in Sitka spruce saplings and effects on sapling health following long term exposure. Environ Pollut. 2004 Jul;130(2):165-76.


Trichloroacetic acid (TCA, CCl (3) COOH) has been associated with forest damage but the source of TCA to trees is poorly characterised.
1(0,0,0,1) Details
12828562 Glabinski AR, Bielecki B, Ransohoff RM: Chemokine upregulation follows cytokine expression in chronic relapsing experimental autoimmune encephalomyelitis. Scand J Immunol. 2003 Jul;58(1):81-8.


Phasic upregulation of gene expression for chemokines T-cell activation gene 3 (TCA-3)/CCL1, monocyte chemoattractant protein-1 (MCP-1)/CCL2, macrophage inflammatory protein-1 alpha (MIP-1alpha)/CCL3, MIP-1beta/CCL4, regulated on activation normal T cell expressed and secreted (RANTES)/CCL5 and MIP-2/CXCL2-3 as well as cytokines tumour necrosis factor-alpha (TNF-alpha), -beta, LT-beta, interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) in the CNS was observed during attacks of ChREAE.
1(0,0,0,1) Details