Protein Information

Name uncoupling protein 2
Synonyms Mitochondrial uncoupling protein 2; SLC25A8; UCP 2; UCP2; UCPH; UPCH; Uncoupling protein 2; Uncoupling protein 2s

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19480693 Fine EJ, Miller A, Quadros EV, Sequeira JM, Feinman RD: Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Int. 2009 May 29;9:14.

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17726146 Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ: Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.

Soleus muscle GLUT4 expression was decreased by twofold, whereas pyruvate dehydrogenase kinase 4, carnitine palmitoyl transferase 1a, and uncoupling protein 2 and 3 expression was increased by two- to threefold at the high dose (P < 0.05).
In separate experiments where mitochondrial coupling was assessed in vivo (day 7), (31) P-MRS was used to measure hindlimb ATP synthesis and (13) C-MRS was used to measure the hindlimb tricarboxylic acid cycle flux (V (tca)).
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12800135 Lee K, Berthiaume F, Stephanopoulos GN, Yarmush ML: Profiling of dynamic changes in hypermetabolic livers. Biotechnol Bioeng. 2003 Aug 20;83(4):400-15.


An ATP balance predicted an increased production of ATP and energy expenditure starting on day 3 post-burn, which correlated with the induction of the oxidative phosphorylation uncoupler uncoupling protein-2.
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