Protein Information

Name S12
Synonyms 5 HT 1B; S12; 5 HT 1D beta; 5 HT1B; 5 HT1DB; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine 1B receptor; HTR1B…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19560494 Wierckx N, Ruijssenaars HJ, de Winde JH, Schmid A, Blank LM: Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: verification and complementation of hypotheses derived from transcriptomics. J Biotechnol. 2009 Aug 20;143(2):124-9. Epub 2009 Jun 26.

3(0,0,0,3) Details
17450135 Bonnin A, Torii M, Wang L, Rakic P, Levitt P: Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci. 2007 May;10(5):588-97. Epub 2007 Apr 22.


We investigated the mechanism by which 5-HT influences TCAs during development. 5-HT (1B) and 5-HT (1D) receptor expression in the fetal forebrain overlaps with that of the axon guidance receptors DCC and Unc5c.
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16325338 Lane RD, Chiaia NL, Kesterson KL, Rhoades RW, Mooney RD: Boundary-limited serotonergic influences on pattern organization in rat sensory cortex. Neurosci Lett. 2006 Mar 6;395(2):165-9. Epub 2005 Dec 1.


In animals exposed to a selective 5-HT1B agonist, 5-nonyloxytryptamine, or elevated endogenous 5-HT, the total areas of TCA aggregates in the PMBSF and those in visual cortex were similar to the controls.
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12351728 Rebsam A, Seif I, Gaspar P: Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice. J Neurosci. 2002 Oct 1;22(19):8541-52.


These defects were corrected in the MAOA/5-HT (1B) double knock-out mice, indicating an effect of the presynaptic 5-HT (1B) receptor on axon branching.
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12422559 Bourin M, David DJ, Jolliet P, Gardier A: [Mechanism of action of antidepressants and therapeutic perspectives] . Therapie. 2002 Jul-Aug;57(4):385-96.


Behavioural, electrophysiological and microdialysis studies have shown that serotonin (5-HT) receptors, mainly 5-HT1A, 5-HT1B and 5-HT2C sub-types, exert a key role in modulating antidepressant activity.
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