Protein Information

Name carbonic anhydrase
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12510387 Aoki S: [Supramolecular chemistry of multinuclear zinc (II) complexes in aqueous solution]. Yakugaku Zasshi. 2002 Dec;122(12):1095-108.


Two new supermolecular frameworks were isolated by self-assembly of a tris (Zn (2+)-cyclen) (Zn3L1) with di-(CA2-) or tri-deprotonated cyanuric acid (CA3-) in aqueous solution.
2(0,0,0,2) Details
14563001 Borelli G, Mayer-Gostan N, Merle PL, De Pontual H, Boeuf G, Allemand D, Payan P: Composition of biomineral organic matrices with special emphasis on turbot (Psetta maxima) otolith and endolymph. Calcif Tissue Int. 2003 Jun;72(6):717-25. Epub 2003 Apr 3.


Our results suggest that both carbonic anhydrase and anticalcifying activities are widespread and play a significant role in the regulation of biomineral formation.
1(0,0,0,1) Details
18056642 Merritt ME, Harrison C, Storey C, Jeffrey FM, Sherry AD, Malloy CR: Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19773-7. Epub 2007 Dec 3.


Dissolved (13) CO (2), the immediate product of the first step of the reaction catalyzed by pyruvate dehydrogenase, was observed with a temporal resolution of approximately 1 s along with H (13) CO (3)(-), the hydrated form of (13) CO (2) generated catalytically by carbonic anhydrase.
1(0,0,0,1) Details
19393749 Lazova G, Naidenova N, Ignatova L, Stefanov D: A pea mutant (costata) expressing higher activity in thylakoid membrane-bound carbonic anhydrase alters PSII downregulation mechanisms. Cell Biol Int. 2009 Aug;33(8):867-73. Epub 2009 Apr 23.

The interaction between photosynthetic electron transport and the activities of the thylakoid associated carbonic anhydrase (tCA), estimated as combined tCA activity in pea plants (Pisum sativum L.
32(0,1,1,2) Details
16571594 Georgalis T, Gilmour KM, Yorston J, Perry SF: Roles of cytosolic and membrane-bound carbonic anhydrase in renal control of acid-base balance in rainbow trout, Oncorhynchus mykiss. Am J Physiol Renal Physiol. 2006 Aug;291(2):F407-21. Epub 2006 Mar 28.

Although tCA IV mRNA was elevated after 24 h of hypercapnia, tCA IV protein levels were unaltered.
7(0,0,0,7) Details
17525468 Ladner CL, Turner RJ, Edwards RA: Development of indole chemistry to label tryptophan residues in protein for determination of tryptophan surface accessibility. Protein Sci. 2007 Jun;16(6):1204-13.


In this study, tryptophan residues of carbonic anhydrase are reacted with chloroform, 2,2,2-trichloroethanol (TCE), 2,2,2-trichloroacetate (TCA), or 3-bromo-1-propanol (BP) under UV irradiation at 280 nm.
4(0,0,0,4) Details
19576596 Seo JY, Lee CH, Cho JH, Choi JH, Yoo KY, Kim DW, Park OK, Li H, Choi SY, Hwang IK, Won MH: Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes. J Neurol Sci. 2009 Oct 15;285(1-2):88-94. Epub 2009 Jul 2.


In this study, we observed the neuroprotective effects of ebselen against ischemic damage and on GABA shunt enzymes such as glutamic acid decarboxylase 67 (GAD67), GABA transaminse (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) in the hippocampal CA1 region after 5 min of transient forebrain ischemia in gerbils.
2(0,0,0,2) Details