Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
15501392 Blossom SJ, Pumford NR, Gilbert KM: Activation and attenuation of apoptosis of CD4+ T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid. J Autoimmun. 2004 Nov;23(3):211-20.

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18594181 Lee SK, Choi BK, Kang WJ, Kim YH, Park HY, Kim KH, Kwon BS: MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4+ T cells in herpetic stromal keratitis. Mol Cells. 2008 Jul 31;26(1):67-73. Epub 2008 Jul 2.

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17163140 Stolpnikova VN, Kochergina NI, Karpenko OM, Miroshnichenko IV: [Quantitative changes in characteristics of immunity in longlivers] . Zh Mikrobiol Epidemiol Immunobiol. 2006 Sep-Oct;(6):50-3.


Among CD3+CD4-CD8- T-lymphocytes cells with phenotypes CD3+/-CD4-CD8-CD16- and CD3+CD4-CD16+ were determined.
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15494499 Singh UP, Singh S, Ravichandran P, Taub DD, Lillard JW Jr: Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J Immunol. 2004 Nov 1;173(9):5509-16.


These CCR8 ligands significantly enhanced Ag-specific serum and mucosal Abs through increasing Th2 cytokine secretion by CD4+ T cells.
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19010625 Yao K, Sato K, Usui D, Kurihara R, Okamoto M, Iguchi Y, Nishiyama K: Chemosurgery with trichloroacetic acid for allergic rhinitis: evaluation of the efficacy in terms of inhibition of Th2 cell infiltration. Auris Nasus Larynx. 2009 Jun;36(3):292-9. Epub 2008 Nov 17.


Th2 cell counts, defined as counts of cells positive for anti-CD4 antibody and anti-CKR4 antibody (double-positive cells) were obtained for comparison.
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16237081 Lopez MV, Adris SK, Bravo AI, Chernajovsky Y, Podhajcer OL: IL-12 and IL-10 expression synergize to induce the immune-mediated eradication of established colon and mammary tumors and lung metastasis. J Immunol. 2005 Nov 1;175(9):5885-94.


The antitumor effect of the combined immunotherapy was mainly dependent on CD8+ cells although CD4+ T cells also played a role.
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