Protein Information

Name c Myc
Synonyms MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16014735 Tao L, Wang W, Li L, Kramer PK, Pereira MA: DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney. Toxicol Sci. 2005 Oct;87(2):344-52. Epub 2005 Jul 13.


We have reported that, in mouse liver, methionine prevented DCA- and TCA-induced hypomethylation of the c-myc gene.
4(0,0,0,4) Details
15342954 Tao L, Wang W, Li L, Kramer PM, Pereira MA: Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver. Toxicol Sci. 2004 Nov;82(1):62-9. Epub 2004 Sep 1.


Hypomethylation of the c-myc gene was observed in mice after 7 days of DBA exposure.
3(0,0,0,3) Details
17594473 Chiu KP, Ariyaratne P, Xu H, Tan A, Ng P, Liu ET, Ruan Y, Wei CL, Sung WK: Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes. BMC Cancer. 2007 Jun 26;7:109.


Expression levels of c-Myc and Trp53 were also higher in melanoma.
1(0,0,0,1) Details
19033189 Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. Epub 2008 Nov 24.


Here, we report that the transcriptional regulatory properties of the oncogene Myc coordinate the expression of genes necessary for cells to engage in glutamine catabolism that exceeds the cellular requirement for protein and nucleotide biosynthesis.
1(0,0,0,1) Details