Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19495707 Gaudet R, Brochu M: Renal and cardiac Na+-K +-ATPase and aconitase in a rat model of fetal programming. Methods Mol Biol. 2009;550:225-37.

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15277511 Slomiany MG, Rosenzweig SA: IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2838-47.


Cells grown on Transwell inserts were probed with antibodies to the Na (+)/K (+)-ATPase alpha-1 subunit and either the alpha or beta subunits of the IGF-1 receptor and visualized in Z-section using confocal microscopy.
2(0,0,0,2) Details
16390870 Oberdorf J, Carlson EJ, Skach WR: Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein. J Cell Sci. 2006 Jan 15;119(Pt 2):303-13. Epub 2006 Jan 3.

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16980490 Noda S, Takezawa Y, Mizutani T, Asakura T, Nishiumi E, Onoe K, Wada M, Tomita F, Matsushita K, Yokota A: Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase. J Bacteriol. 2006 Oct;188(19):6869-76.

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15958496 Tyagi W, Rajagopal D, Singla-Pareek SL, Reddy MK, Sopory SK: Cloning and regulation of a stress-regulated Pennisetum glaucum vacuolar ATPase c gene and characterization of its promoter that is expressed in shoot hairs and floral organs. Plant Cell Physiol. 2005 Aug;46(8):1411-22. Epub 2005 Jun 15.


We have cloned and characterized the cDNA, genomic clone and upstream promoter region of a vacuolar ATPase (V-ATPase) c subunit (PgVHA-c1) from Pennisetum glaucum.
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16413626 Mohankumar K, Ramasamy P: Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. Virus Res. 2006 Jun;118(1-2):130-5. Epub 2006 Jan 18.


The activities of membrane bound phosphatases (Na (+) K (+) ATPase, Ca (2+) ATPase, Mg (2+) ATPase and Total ATPase), transaminases (alanine transaminase (ALT) and aspartate transaminase (AST)) and mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), alpha-ketoglutarate dehydrogenase (KGDH), NADH dehydrogenase, cytochrome C oxidase) in WSSV-infected tissues (hemolymph, hepatopancreas, gills and muscle) of Fenneropenaeus indicus were determined at intervals after WSSV infection (0, 24, 48, 72 and after 72 h (moribund)).
1(0,0,0,1) Details
16857877 Walsh PJ, Kajimura M, Mommsen TP, Wood CM: Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. J Exp Biol. 2006 Aug;209(Pt 15):2929-38.


Several enzymes showed a large increase in activity post-feeding, including beta-hydroxybutyrate dehydrogenase in rectal gland and liver, and in rectal gland, isocitrate dehydrogenase, citrate synthase, lactate dehydrogenase, aspartate amino transferase, alanine amino transferase, glutamine synthetase and Na (+)/K (+) ATPase.
1(0,0,0,1) Details
16571594 Georgalis T, Gilmour KM, Yorston J, Perry SF: Roles of cytosolic and membrane-bound carbonic anhydrase in renal control of acid-base balance in rainbow trout, Oncorhynchus mykiss. Am J Physiol Renal Physiol. 2006 Aug;291(2):F407-21. Epub 2006 Mar 28.

Although tCA IV mRNA was elevated after 24 h of hypercapnia, tCA IV protein levels were unaltered.
The CA IV-containing tubule cells were enriched with Na (+)-K (+)-ATPase.
1(0,0,0,1) Details
12841626 Malarkodi KP, Balachandar AV, Varalakshmi P: The influence of lipoic acid on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 2003 May;247(1-2):15-22.


The transmembrane enzymes namely the Na+,K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and the brush-border enzyme alkaline phosphatase also showed a decrease in their activities.
1(0,0,0,1) Details
19390955 Liu T, O'Rourke B: Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart. J Bioenerg Biomembr. 2009 Apr;41(2):127-32.


The kinetics of mitochondrial Ca (2+) ([Ca (2+)](m)) uptake remains unclear, and we review the debate on this subject in this article. [Ca (2+)](m) has multiple targets in oxidative phosphorylation including the F1/FO ATPase, the adenine nucleotide translocase, and Ca (2+)-sensitive dehydrogenases (CaDH) of the tricarboxylic acid (TCA) cycle.
1(0,0,0,1) Details
15595725 Goodchild A, Raftery M, Saunders NF, Guilhaus M, Cavicchioli R: Biology of the cold adapted archaeon, Methanococcoides burtonii determined by proteomics using liquid chromatography-tandem mass spectrometry. J Proteome Res. 2004 Nov-Dec;3(6):1164-76.


DNA replication and cell division involves eucaryotic-like histone and MC1-family DNA binding proteins, and 2 bacterial-like FtsZ proteins.
1(0,0,0,1) Details
12557308 Yoon SH, Han MJ, Lee SY, Jeong KJ, Yoo JS: Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture. Biotechnol Bioeng. 2003 Mar 30;81(7):753-67.


The expression of genes of TCA cycle enzymes, NADH dehydrogenase and ATPase, was up-regulated during the exponential fed-batch period and was down-regulated afterward.
1(0,0,0,1) Details
17594473 Chiu KP, Ariyaratne P, Xu H, Tan A, Ng P, Liu ET, Ruan Y, Wei CL, Sung WK: Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes. BMC Cancer. 2007 Jun 26;7:109.


The most significantly altered pathways were metabolic pathways, including upregulated pathways: purine metabolism, aminophosphonate metabolism, tyrosine metabolism, selenoamino acid metabolism, galactose utilization, nitrobenzene degradation, and bisphenol A degradation; and downregulated pathways: oxidative phosphorylation, ATPase synthesis, TCA cycle, pyruvate metabolism, and glutathione metabolism.
1(0,0,0,1) Details
19744494 O'Donnell JM, Pound K, Xu X, Lewandowski ED: SERCA1 expression enhances the metabolic efficiency of improved contractility in post-ischemic heart. J Mol Cell Cardiol. 2009 Nov;47(5):614-21. Epub 2009 Sep 8.


Overexpression of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA1) in hearts has recently been reported to reduce dysfunction at reperfusion.
1(0,0,0,1) Details
18452229 Li J, Wu XD, Hao ST, Wang XJ, Ling HQ: Proteomic response to iron deficiency in tomato root. Proteomics. 2008 Jun;8(11):2299-311.


Proteins involved in methionine synthesis, cell wall synthesis, mitochondria ATP synthesis, vacuole ATPase, HSP70/90, etc. also revealed enhanced expression under iron deficiency, while proteins about redox homeostasis, transcription factors, kinases, etc. showed diversified changes.
1(0,0,0,1) Details
15968059 Chatterjee I, Becker P, Grundmeier M, Bischoff M, Somerville GA, Peters G, Sinha B, Harraghy N, Proctor RA, Herrmann M: Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death. J Bacteriol. 2005 Jul;187(13):4488-96.


These data demonstrate the critical role of the ClpC ATPase in regulating the TCA cycle and implicate ClpC as being important for recovery from the stationary phase and also for entering the death phase.
1(0,0,0,1) Details
15060153 Lawrence CL, Botting CH, Antrobus R, Coote PJ: Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol. 2004 Apr;24(8):3307-23.


To counteract the cation chelating activity of citric acid, the plasma membrane Ca (2+) channel, CCH1, and a functional vacuolar membrane H (+)-ATPase were found to be essential for optimal adaptation.
1(0,0,0,1) Details
12668482 Cortassa S, Aon MA, Marban E, Winslow RL, O'Rourke B: An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J. 2003 Apr;84(4):2734-55.


The kinetic component of the model includes effectors of the TCA cycle enzymes regulating production of NADH and FADH (2), which in turn are used by the electron transport chain to establish a proton motive force (Delta mu (H)), driving the F (1) F (0)-ATPase.
1(0,0,0,1) Details
17610509 Saunders AM, Mabbett AN, McEwan AG, Blackall LL: Proton motive force generation from stored polymers for the uptake of acetate under anaerobic conditions. FEMS Microbiol Lett. 2007 Sep;274(2):245-51. Epub 2007 Jul 4.


Stored polymers were used to generate the PMF -Accumulibacter used phosphate efflux through the Pit transporter, while Competibacter generated a PMF by proton efflux through the ATPase and fumarate reductase in the reductive TCA cycle.
1(0,0,0,1) Details
16581157 Bierczynska-Krzysik A, Bonar E, Drabik A, Noga M, Suder P, Dylag T, Dubin A, Kotlinska J, Silberring J: Rat brain proteome in morphine dependence. Neurochem Int. 2006 Sep;49(4):401-6. Epub 2006 Apr 3.

Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem mass spectrometry, allowed for identification of eleven potential dependence markers, mainly cytoplasmic and mitochondrial enzymes, e.g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families.
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20211125 Karnes HE, Scaletty PN, Durham D: Histochemical and fluorescent analyses of mitochondrial integrity in chick auditory neurons following deafferentation. J Am Acad Audiol. 2010 Mar;21(3):204-18.


Histochemical staining intensities for three mitochondrial enzymes, succinate dehydrogenase (SDH), cytochrome c oxidase (CO), and ATP synthase (ATPase) were measured in individual neurons and compared in ipsilateral and contralateral NM.
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19931487 Chatterjee I, Neumayer D, Herrmann M: Senescence of staphylococci: using functional genomics to unravel the roles of ClpC ATPase during late stationary phase. Int J Med Microbiol. 2010 Feb;300(2-3):130-6. Epub 2009 Nov 20.

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