| Name | pyruvate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | Pyruvate dehydrogenase; Pyruvate dehydrogenases |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17008113 | Liu L, Li Y, Zhu Y, Du G, Chen J: Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and level. Metab Eng. 2007 Jan;9(1):21-9. Epub 2006 Aug 12. Increasing the concentrations of and could selectively open the valve of carbon flux from to pyruvate dehydrogenase complex, the pyruvate carboxylase (PC) pathway and the channel into the TCA cycle, leading to the over-production of alpha-ketoglutarate. |
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| 12125819 | Inoue K, Chen J, Kato I, Inouye M: Specific growth inhibition by of an Escherichia coli strain expressing Era-dE, a dominant negative Era mutant. J Mol Microbiol Biotechnol. 2002 Jul;4(4):379-88. and NAD are essential cofactors for the activities of pyruvate dehydrogenase complex, dehydrogenase complex and cleavage enzyme complex. |
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| 15183011 | Zwingmann C, Leibfritz D, Hazell AS: Brain energy metabolism in a sub-acute rat model of neurotoxicity: an ex vivo nuclear magnetic resonance study using [1-13C] Neurotoxicology. 2004 Jun;25(4):573-87. In parallel, treatment resulted in stimulation of flux through pyruvate dehydrogenase (PDH), leading to accumulation of [4-13C] [4-13C] and [2-13C] to 168, 247 and 144% of control, respectively. |
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| 12868651 | Herbert M, Kraiss A, Hilpert AK, Schlor S, Reidl J: Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism. Int J Med Microbiol. 2003 Jun;293(2-3):145-52. Since LpdA is a functional subunit of both pyruvate dehydrogenase (aceEF) and alpha-ketoglutarate dehydrogenase (sucAB) the phenotype of the lpdA mutant was further explored by creating separate knockout mutants in the sucAB and aceEF loci. |
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| 17391017 | De Palma S, Ripamonti M, Vigano A, Moriggi M, Capitanio D, Samaja M, Milano G, Cerretelli P, Wait R, Gelfi C: Metabolic modulation induced by chronic hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue. J Proteome Res. 2007 May;6(5):1974-84. Epub 2007 Mar 29. Up-regulation of the hypoxia markers hypoxia inducible factor 1 (HIF-1alpha) and pyruvate dehydrogenase kinase 1 (PDK1) was also observed, suggesting that in vivo adaptation to hypoxia requires an active metabolic switch. |
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| 18336823 | Fleige T, Pfaff N, Gross U, Bohne W: Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii. Int J Parasitol. 2008 Aug;38(10):1121-32. Epub 2008 Feb 13. It was recently demonstrated that the single pyruvate dehydrogenase complex (PDH) in T. gondii is exclusively localised inside the apicoplast but absent in the mitochondrion. |
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| 17726146 | Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ: Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28. Soleus muscle GLUT4 expression was decreased by twofold, whereas pyruvate dehydrogenase kinase 4, palmitoyl transferase 1a, and uncoupling protein 2 and 3 expression was increased by two- to threefold at the high dose (P < 0.05). In separate experiments where mitochondrial coupling was assessed in vivo (day 7), (31) P-MRS was used to measure hindlimb ATP synthesis and (13) C-MRS was used to measure the hindlimb tricarboxylic acid cycle flux (V (tca)). |
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| 18937252 | Vigano A, Ripamonti M, De Palma S, Capitanio D, Vasso M, Wait R, Lundby C, Cerretelli P, Gelfi C: Proteins modulation in human skeletal muscle in the early phase of adaptation to hypobaric hypoxia. Proteomics. 2008 Nov;8(22):4668-79. Parenthetically, hypoxia markers such as hypoxia inducible factor 1 alpha (HIF-1alpha) and pyruvate dehydrogenase kinase 1 (PDK1) were still at the pre-hypoxia levels, whereas the mammalian target of rapamycin (mTOR), a marker of protein synthesis, was reduced. |
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| 16575559 | Simpson NE, Khokhlova N, Oca-Cossio JA, Constantinidis I: Insights into the role of anaplerosis in insulin secretion: A 13C NMR study. Diabetologia. 2006 Jun;49(6):1338-48. Epub 2006 Mar 31. A model containing a single pool of an entrance to the TCA cycle via the pyruvate dehydrogenase complex, and two anaplerotic entrances, one through pyruvate carboxylase and another through an undefined (by the modelling program) source, provided the best fit to the data under all conditions tested, for all cell lines. |
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| 12793977 | Lloyd S, Brocks C, Chatham JC: Differential modulation of lactate, and oxidation by insulin and dichloroacetate in the rat heart. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H163-72. Therefore, the purpose of this study was to determine the contributions of lactate, and to energy production in the isolated, perfused rat heart over a range of insulin concentrations and after activation of pyruvate dehydrogenase with dichloroacetate (DCA). |
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| 18849332 | Olson AK, Hyyti OM, Cohen GA, Ning XH, Sadilek M, Isern N, Portman MA: Superior cardiac function via anaplerotic in the immature swine heart after cardiopulmonary bypass and reperfusion. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2315-20. Epub 2008 Oct 10. Hemodynamic data were collected. 13C NMR spectroscopy was used to determine the fraction of entering the TCA cycle via carboxylation (PC) to total TCA cycle entry (PC plus decarboxlyation via pyruvate dehydrogenase). |
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| 16750927 | Hoon Yang T, Wittmann C, Heinzle E: Respirometric 13C flux analysis--Part II: in vivo flux estimation of -producing Corynebacterium glutamicum. Metab Eng. 2006 Sep;8(5):432-46. Epub 2006 Apr 28. At key branch points, 68+/-5% of were observed to be metabolized into pentose phosphate pathway and 48+/-1% of into TCA cycle via pyruvate dehydrogenase. |
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| 18056642 | Merritt ME, Harrison C, Storey C, Jeffrey FM, Sherry AD, Malloy CR: Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19773-7. Epub 2007 Dec 3. Dissolved (13) CO (2), the immediate product of the first step of the reaction catalyzed by pyruvate dehydrogenase, was observed with a temporal resolution of approximately 1 s along with H (13) CO (3)(-), the hydrated form of (13) CO (2) generated catalytically by carbonic anhydrase. |
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| 16765624 | Simpson NE, Han Z, Berendzen KM, Sweeney CA, Oca-Cossio JA, Constantinidis I, Stacpoole PW: Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. Mol Genet Metab. 2006 Sep-Oct;89(1-2):97-105. Epub 2006 Jun 12. The pyruvate dehydrogenase complex (PDC) is integral to metabolism and energetics. |
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| 17346854 | Johansen ML, Bak LK, Schousboe A, Iversen P, Sorensen M, Keiding S, Vilstrup H, Gjedde A, Ott P, Waagepetersen HS: The metabolic role of in detoxification of in cultured mouse neurons and astrocytes. Neurochem Int. 2007 Jun;50(7-8):1042-51. Epub 2007 Feb 6. Catabolism of the branched-chain amino acid provides both and thus by-passing both the pyruvate dehydrogenase and the alpha-ketoglutarate dehydrogenase steps. |
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| 15806547 | Phue JN, Noronha SB, Hattacharyya R, Wolfe AJ, Shiloach J: metabolism at high density growth of E. coli B and E. coli K: differences in metabolic pathways are responsible for efficient utilization in E. coli B as determined by microarrays and Northern blot analyses. Biotechnol Bioeng. 2005 Jun 30;90(7):805-20. The inactivation of the gluconeogenesis enzyme synthetase (ppsA), the activation of the anaplerotic sfcA shunt, and low and stable pyruvate dehydrogenase (aceE, aceF) cause accumulation which is converted to by oxidase B. |
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| 12448701 | Rozen Y, Larossa RA, Templeton LJ, Smulski DR, Belkin S: Gene expression analysis of the response by Escherichia coli to seawater. Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):15-25. Induced genes were numerous in groups specifying the degradation of small molecules (carbon compounds, amino acids and fatty acids), energy metabolism (aerobic and anaerobic respiration, pyruvate dehydrogenase and TCA cycle), chemotaxis and mobility, flagella biosynthesis, surface structures and phage related functions. |
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| 19526285 | Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK: Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res. 2009 Oct;16(3):186-93. Epub 2009 Mar 5. In addition to KGDH, we assessed the activities and substrate-mediated respiration of complex I, pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and mitochondrial aconitase in the absence and presence of complex-specific inhibitors in specific and mixed substrate conditions in mitochondria from our MAO-B elevated cells versus controls. |
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| 16962353 | Zhu J, Shalel-Levanon S, Bennett G, San KY: Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labeling experiments. Metab Eng. 2006 Nov;8(6):619-27. Epub 2006 Aug 7. The fluxes through pyruvate dehydrogenase (PDH) and tricarboxylic acid (TCA) cycle were found to be lower in the arcA mutant and the arcAfnr double mutant strains than that in the wild-type strain, although the expression of the genes involved in these pathways have been proved to be derepressed in the mutant strains ([Shalel-Levanon, S., San, K.Y., Bennett, G.N., 2005a. |
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| 12948633 | Gerstmeir R, Wendisch VF, Schnicke S, Ruan H, Farwick M, Reinscheid D, Eikmanns BJ: metabolism and its regulation in Corynebacterium glutamicum. J Biotechnol. 2003 Sep 4;104(1-3):99-122. These genes, thus also belonging to the stimulon of C. glutamicum, include genes coding for TCA cycle enzymes (e.g. aconitase and succinate dehydrogenase), for gluconeogenesis (phosphoenolpyruvate carboxykinase), for glycolysis (pyruvate dehydrogenase E1) and genes coding for proteins with hitherto unknown function. |
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| 19716393 | Pathania D, Millard M, Neamati N: Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. Adv Drug Deliv Rev. 2009 Nov 30;61(14):1250-75. Epub 2009 Aug 27. Moreover, agents targeting the PDC/PDK (pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase) interaction are being studied for reversal of Warburg effect. |
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| 15454400 | Roberts PA, Loxham SJ, Poucher SM, Constantin-Teodosiu D, Greenhaff PL: provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E327-34. Epub 2004 Sep 28. We examined the effects of increasing and availability at rest, independent of pyruvate dehydrogenase complex (PDC) activation, on energy production and tension development during the rest-to-work transition in canine skeletal muscle. |
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| 16310273 | Li M, Ho PY, Yao S, Shimizu K: Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by 13C-labeling experiments. J Biotechnol. 2006 Mar 23;122(2):254-66. Epub 2005 Nov 23. The dehydrogenase (LPD) encoded by lpdA gene is a component of the pyruvate dehydrogenase complex (PDHc), alpha-ketoglutarate dehydrogenase (AKGDH) and the cleavage multi-enzyme (GCV) systems. |
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| 17940539 | Serres S, Raffard G, Franconi JM, Merle M: Close coupling between astrocytic and neuronal metabolisms to fulfill anaplerotic and energy needs in the rat brain. J Cereb Blood Flow Metab. 2008 Apr;28(4):712-24. Epub 2007 Oct 17. C2 enrichment and ratio between pyruvate carboxylase and pyruvate dehydrogenase activity (PC/PDH) were determined from and labeling. |
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| 15337301 | Bubber P, Ke ZJ, Gibson GE: Tricarboxylic acid cycle enzymes following thiamine deficiency. . Neurochem Int. 2004 Dec;45(7):1021-8. In the current studies, the pyruvate dehydrogenase complex (PDHC) and all of enzymes of the TCA cycle were measured in the brains of TD mice. |
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| 16496303 | Zwingmann C, Bilodeau M: Metabolic insights into the hepatoprotective role of in mouse liver. Hepatology. 2006 Mar;43(3):454-63. Hepatocellular metabolites and high-energy phosphates were quantified from mouse liver extracts by 1H- and 31P-NMR (nuclear magnetic resonance) spectroscopy. 13C-NMR-isotopomer analysis was used to measure [U-13C] metabolism through pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC). |
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| 12646315 | Miccheli A, Puccetti C, Capuani G, Di Cocco ME, Giardino L, Calza L, Battaglia A, Battistin L, Conti F: [1-13C] entry in neuronal and astrocytic intermediary metabolism of aged rats. Brain Res. 2003 Mar 14;966(1):116-25. A significant increase in pyruvate carboxylase/pyruvate dehydrogenase activity (PC/PDH) in the synthesis of in nicergoline-treated aged rats is consistent with an increase in the transport of from glia to neurons for conversion into |
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| 18954447 | Huicho L, Xing G, Qualls C, Rivera-Ch M, Gamboa JL, Verma A, Appenzeller O: Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness. BMC Pediatr. 2008 Oct 27;8:47. Pyruvate dehydrogenase kinase 1 (PDK1) and HIF prolyl hydroxylase 3 (HPH3) mRNA expressions were lowest in children of CMS fathers at altitude. |
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| 16517405 | Kim JW, Tchernyshyov I, Semenza GL, Dang CV: HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006 Mar;3(3):177-85. |
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| 16980458 | Soo PC, Horng YT, Lai MJ, Wei JR, Hsieh SC, Chang YL, Tsai YH, Lai HC: Pirin regulates catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity. J Bacteriol. 2007 Jan;189(1):109-18. Epub 2006 Sep 15. |
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| 15852400 | Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE: Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol. 2005 May;57(5):695-703. Significant (p < 0.01) decreases occurred in the activities of the pyruvate dehydrogenase complex (-41%), isocitrate dehydrogenase (-27%), and the alpha-ketoglutarate dehydrogenase complex (-57%). |
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| 12662309 | Yui R, Iketani S, Mikami T, Kubo T: Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility. Plant J. 2003 Apr;34(1):57-66. |
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| 12439292 | Choi IY, Lei H, Gruetter R: Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total consumption with glutamatergic action. J Cereb Blood Flow Metab. 2002 Nov;22(11):1343-51. The exchange rate between cytosolic and mitochondrial Vx, was equal to the rate of neuronal pyruvate dehydrogenase flux. |
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| 15188415 | Voigt B, Schweder T, Becher D, Ehrenreich A, Gottschalk G, Feesche J, Maurer KH, Hecker M: A proteomic view of cell physiology of Bacillus licheniformis. Proteomics. 2004 May;4(5):1465-90. In cells grown in the presence of a significant increase of the amount of some glycolytic enzymes (TpiA, GapA, Pgk, Pgm, Eno, Pyk) and of the pyruvate dehydrogenase (PdhA-D) was found. |
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| 16736046 | Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L: improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab. 2007 Feb;27(2):304-15. Epub 2006 May 24. Pyruvate metabolism was primarily via pyruvate dehydrogenase, with some via carboxylation. |
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| 16517406 | Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC: HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial consumption. Cell Metab. 2006 Mar;3(3):187-97. However, we find that while HIF-1 stimulates glycolysis, it also actively represses mitochondrial function and consumption by inducing pyruvate dehydrogenase kinase 1 (PDK1). |
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| 16269086 | Frick O, Wittmann C: Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb Cell Fact. 2005 Nov 3;4:30. S. cerevisiae exhibited a by-pass of pyruvate dehydrogenase in all physiological regimes. |
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| 16504342 | Haberg A, Qu H, Sonnewald U: and metabolism in transient and permanent middle cerebral artery occlusion in rat: importance of astrocytes for neuronal survival. Neurochem Int. 2006 May-Jun;48(6-7):531-40. Epub 2006 Feb 28. The results demonstrated four metabolic events that distinguished the reperfused penumbra from the ischemic core. (1) Improved astrocytic metabolism demonstrated by increased amounts of [4,5-(13) C] and improved oxidation. (2) Neuronal mitochondrial activity was better preserved although the flux of via pyruvate dehydrogenase into the tricarboxylic acid (TCA) cycle in glutamatergic and GABAergic neurons was halved. |
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| 17521432 | Laughton JD, Bittar P, Charnay Y, Pellerin L, Kovari E, Magistretti PJ, Bouras C: Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase. BMC Neurosci. 2007 May 23;8:35. |
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| 18094529 | Choi YJ, Uhm SJ, Song SJ, Song H, Park JK, Kim T, Park C, Kim JH: Cytochrome c upregulation during capacitation and spontaneous acrosome reaction determines the fate of pig sperm cells: linking proteome analysis. J Reprod Dev. 2008 Feb;54(1):68-83. Epub 2007 Dec 18. After induction of capacitation in vitro, the well-established markers of the capacitation (lactadherin P47, acrosomal protein SP-10 precursor, prohibitin, proteasomes, DJ-1 protein and arylsulfatase-A) and TCA cycle proteins (isocitrate dehydrogenase, malate dehydrogenase and pyruvate dehydrogenase) were identified. |
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| 17689798 | Wittmann C, Weber J, Betiku E, Kromer J, Bohm D, Rinas U: Response of fluxome and metabolome to temperature-induced recombinant protein synthesis in Escherichia coli. J Biotechnol. 2007 Dec 1;132(4):375-84. Epub 2007 Jul 10. The strong increase of flux into overflow pathways, especially towards was most likely caused by a flux redirection from pyruvate dehydrogenase to oxidase. |
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| 16980490 | Noda S, Takezawa Y, Mizutani T, Asakura T, Nishiumi E, Onoe K, Wada M, Tomita F, Matsushita K, Yokota A: Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase. J Bacteriol. 2006 Oct;188(19):6869-76. Genetic and biochemical analyses of the mutant revealed the downregulation of many TCA cycle enzymes, including citrate synthase, and the upregulation of the pyruvate dehydrogenase complex in both transcription and enzyme activities. |
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| 16885387 | Nissim I, Horyn O, Daikhin Y, Nissim I, Luhovyy B, Phillips PC, Yudkoff M: Ifosfamide-induced nephrotoxicity: mechanism and prevention. Cancer Res. 2006 Aug 1;66(15):7824-31. Inhibition of C-I was associated with a significant elevation of depletion of [NAD], and decreased flux through pyruvate dehydrogenase and the TCA cycle. |
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| 16517402 | Simon MC: Coming up for air: HIF-1 and mitochondrial consumption. Cell Metab. 2006 Mar;3(3):150-1. Two papers in this issue of Cell Metabolism (Kim et al., 2006; Papandreou et al., 2006) demonstrate that HIF-1 also influences mitochondrial function, suppressing both the TCA cycle and respiration by inducing pyruvate dehydrogenase kinase 1 (PDK1). |
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| 17426345 | Pan JG, Mak TW: Metabolic targeting as an anticancer strategy: dawn of a new era? . Sci STKE. 2007 Apr 10;2007(381):pe14. As a result of a spectrum of mitochondrial defects, tumor cells often preferentially use glycolysis to generate even in the presence of a phenomenon known as aerobic glycolysis, or the "Warburg effect." Dichloroacetate (DCA) is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase (PDH), a gatekeeping enzyme for the entry of into the mitochondrial tricarboxylic acid (TCA) cycle. |
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| 12493853 | Marillia EF, Micallef BJ, Micallef M, Weninger A, Pedersen KK, Zou J, Taylor DC: Biochemical and physiological studies of Arabidopsis thaliana transgenic lines with repressed expression of the mitochondrial pyruvate dehydrogenase kinase. J Exp Bot. 2003 Jan;54(381):259-70. |
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| 17316901 | Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B: Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem Int. 2007 Apr;50(5):703-9. Epub 2007 Jan 20. In contrast, formation of from [U-(14) C] in awake rats (which reflects the passage of (14) C through the whole TCA cycle) and activities of pyruvate dehydrogenase, citrate synthase, alpha-ketoglutarate dehydrogenase, and fumarase in white structures were 10-23% of cortical values, optic nerve showing the lowest values. |
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| 20222442 | Zhang D, Liu L, Du G, Chen J: [Physiological function of alpha-ketoglutarate dehydrogenase complex in Torulopsis glabrata]. Wei Sheng Wu Xue Bao. 2009 Dec 4;49(12):1584-9. But the specific activities of pyruvate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase increased by 58.1%, 33.3% and 32.5%, respectively; (c) the intracellular concentration of was reduced by 49.9%, while the intracellular concentration of and alpha-ketoglutarate was higher 172.7%, 66.1% and 41.1% than the corresponding values of the control; (d) The content of -family amino acid was 29.3% lower while the level of -family amino acid and -family amino acid were 34.7% and 26.8% higher than that of control. |
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| 17263682 | Bartnik BL, Hovda DA, Lee PW: metabolism after traumatic brain injury: estimation of pyruvate carboxylase and pyruvate dehydrogenase flux by mass isotopomer analysis. J Neurotrauma. 2007 Jan;24(1):181-94. |
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