Protein Information

Name fatty acid synthase
Synonyms FAS; FAS; FASN; FASN protein; Fatty acid synthase; OA 519; FASN proteins; Fatty acid synthases…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
17565694 Knowles LM, Smith JW: Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. BMC Genomics. 2007 Jun 12;8:168.

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15617971 Zhang Y, Guo C, Yu G: A pilot study of fatty acid metabolism in oral squamous cell carcinoma. . Int J Oral Maxillofac Surg. 2005 Jan;34(1):78-81.


The effects of cerulenin, a specific, potent, noncompetitive inhibitor of fatty acid synthase (FAS), on growth of TCA-83 cells and normal gingival fibroblasts was determined by the MTT method, and the effect of cerulenin on apoptosis was determined by electrophoresis of cellular DNA.
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15989236 Wang P, Zhuang YP, Chu J, Zhang SL: [Regulatory effects of ammonium ions on the biosynthesis of meilingmycin] . Wei Sheng Wu Xue Bao. 2005 Jun;45(3):405-9.


The results suggest that glucose-6-phosphate dehydrogenase, citrate synthase, succinate dehydrogenase and fatty acid synthase are stimulated by higher concentration of ammonium ions, while valine dehydrogenase and methylmalonyl-CoA carboxyltransferase are inhibited.
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