Protein Information

Name HDAC
Synonyms HD7; HDAC 7; HDAC7; HD7B; HD9; HDAC; HDAC 9; HDAC7B…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16839657 Chan M, Tan DS, Wong SH, Sim TS: A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization. Biochimie. 2006 Oct;88(10):1367-75. Epub 2006 Jun 22.


These eukaryotic cells serve as an in vitro living system for studying the cellular destinations of four mitochondrial-targeted TCA cycle proteins (citrate synthase, CS; isocitrate dehydrogenase, ICDH; branched chain alpha-keto-acid dehydrogenase E1alpha subunit, BCKDH; succinate dehydrogenase flavoprotein-subunit, SDH), two nuclear-targeted proteins (histone deacetylase, HDAC; RNA polymerase, RPOL), two apicoplast-targeted proteins (pyruvate kinase 2, PK2; glutamate dehydrogenase, GDH), and two cytoplasmic resident proteins (malate dehydrogenase, MDH; glycerol kinase, GK).
1(0,0,0,1) Details
17767915 Kim YS, Song YM, Kwon HJ: Functional analysis of a histone deacetylase-like protein of Thermus caldophilus GK24 in mammalian cell. Biochem Biophys Res Commun. 2007 Nov 3;362(4):995-1000. Epub 2007 Aug 28.

To explore the function of Tca HDAC in mammalian cells, Tca HDAC gene expressing vector was transfected into a human fibrosarcoma cell line, HT1080.
106(1,1,5,6) Details
17632079 Song YM, Kim YS, Kim D, Lee DS, Kwon HJ: Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24. Biochem Biophys Res Commun. 2007 Sep 14;361(1):55-61. Epub 2007 Jul 9.

The Tca HDAC gene was over-expressed in Escherichia coli using a Glutathione-S transferase (GST) fusion vector (pGEX-4T-1) and the purified protein showed a deacetylase activity toward the fluorogenic substrate for HDAC.
100(1,1,4,5) Details