Protein Information

Name transketolase
Synonyms TK; TKT; TKT 1; TKT1; Transketolase; Transketolase variant; Transketolases; Transketolase variants

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19804861 Sawada K, Taki A, Yamakawa T, Seki M: Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42. J Biosci Bioeng. 2009 Nov;108(5):385-90. Epub 2009 Jul 29.

5(0,0,0,5) Details
12893755 Boros LG, Steinkamp MP, Fleming JC, Lee WN, Cascante M, Neufeld EJ: Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). Blood. 2003 Nov 15;102(10):3556-61. Epub 2003 Jul 31.


RNA ribose isolated from TRMA fibroblasts in thiamine-depleted cultures shows a time-dependent decrease in the fraction of ribose derived via transketolase, a thiamine-dependent enzyme in the pentose cycle.
2(0,0,0,2) Details
19603213 Wu L, Li Z, Ye Q: Enhanced D-ribose biosynthesis in batch culture of a transketolase-deficient Bacillus subtilis strain by citrate. J Ind Microbiol Biotechnol. 2009 Oct;36(10):1289-96. Epub 2009 Jul 15.

2(0,0,0,2) Details
14996808 Kromer JO, Sorgenfrei O, Klopprogge K, Heinzle E, Wittmann C: In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol. 2004 Mar;186(6):1769-84.


A correlation between flux and expression was also observed for glucose-6-phosphate dehydrogenase, transaldolase, and transketolase and for most TCA cycle genes.
1(0,0,0,1) Details
19401345 Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ: Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res. 2009 May 15;15(10):3442-50. Epub 2009 Apr 28.


In addition, oxidative synthesis of RNA ribose from (13) C-glucose via glucose-6-phosphate dehydrogenase was decreased, and RNA synthesis via the nonoxidative transketolase pathway was increased in imatinib-resistant cells.
1(0,0,0,1) Details
16359766 Miccheli A, Tomassini A, Puccetti C, Valerio M, Peluso G, Tuccillo F, Calvani M, Manetti C, Conti F: Metabolic profiling by 13C-NMR spectroscopy: [1,2-13C2] glucose reveals a heterogeneous metabolism in human leukemia T cells. Biochimie. 2006 May;88(5):437-48. Epub 2005 Nov 7.


In particular, the contribution of the glucose-6-phosphate dehydrogenase and transketolase activities to phosphoribosyl-pyrophosphate synthesis was evaluated directly by the determination of isotopomers of the [1'-(13) C], [4',5'-(13) C (2)] ribosyl moiety of nucleotides.
1(0,0,0,1) Details
17880710 Baez-Viveros JL, Flores N, Juarez K, Castillo-Espana P, Bolivar F, Gosset G: Metabolic transcription analysis of engineered Escherichia coli strains that overproduce L-phenylalanine. Microb Cell Fact. 2007 Sep 19;6:30.


ABSTRACT: BACKGROUND: The rational design of L-phenylalanine (L-Phe) overproducing microorganisms has been successfully achieved by combining different genetic strategies such as inactivation of the phosphoenolpyruvate: phosphotransferase transport system (PTS) and overexpression of key genes (DAHP synthase, transketolase and chorismate mutase-prephenate dehydratase), reaching yields of 0.33 (g-Phe/g-Glc), which correspond to 60% of theoretical maximum.
1(0,0,0,1) Details