| Name | aconitase |
|---|---|
| Synonyms | ACO 2; Aconitase; Citrate hydro lyase; ACO2; ACO2 protein; ACONM; Aconitase 2; Citrate hydrolyase aconitase… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19495707 | Gaudet R, Brochu M: Renal and cardiac Na+-K +-ATPase and aconitase in a rat model of fetal programming. Methods Mol Biol. 2009;550:225-37. |
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| 16395550 | Blencke HM, Reif I, Commichau FM, Detsch C, Wacker I, Ludwig H, Stulke J: Regulation of citB expression in Bacillus subtilis: integration of multiple metabolic signals in the pool and by the general regulatory system. Arch Microbiol. 2006 Mar;185(2):136-46. Epub 2006 Jan 5. The syntheses of the enzymes performing the initial reactions of the cycle, citrate synthase, and aconitase, are synergistically repressed by rapidly metabolizable carbon sources and |
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| 15968059 | Chatterjee I, Becker P, Grundmeier M, Bischoff M, Somerville GA, Peters G, Sinha B, Harraghy N, Proctor RA, Herrmann M: Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death. J Bacteriol. 2005 Jul;187(13):4488-96. |
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| 17273855 | Veit A, Polen T, Wendisch VF: Global gene expression analysis of overflow metabolism in Escherichia coli and reduction of aerobic formation. Appl Microbiol Biotechnol. 2007 Feb;74(2):406-21. Epub 2006 Nov 25. A correlation analysis identified that expression of ten genes (sdhCDAB, sucB, sucC, acnB, lpdA, fumC and mdh) encoding the TCA cycle enzymes succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, synthetase, aconitase, fumarase and malate dehydrogenase, respectively, and of the acs-yjcH-actP operon for utilization correlated negatively with formation. |
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| 18337490 | Morgan MJ, Lehmann M, Schwarzlander M, Baxter CJ, Sienkiewicz-Porzucek A, Williams TC, Schauer N, Fernie AR, Fricker MD, Ratcliffe RG, Sweetlove LJ, Finkemeier I: Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis. Plant Physiol. 2008 May;147(1):101-14. Epub 2008 Mar 12. However, there were specific inhibitions of tricarboxylic acid (TCA) cycle enzymes (aconitase and isocitrate dehydrogenase) and an inhibition of TCA cycle flux in isolated mitochondria. |
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| 12730455 | Eisenstein RS, Ross KL: Novel roles for iron regulatory proteins in the adaptive response to iron deficiency. J Nutr. 2003 May;133(5 Suppl 1):1510S-6S. In mammals, this includes the mRNA that encodes the TCA-cycle enzyme mitochondrial aconitase (m-acon). |
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| 12631716 | McCammon MT, Epstein CB, Przybyla-Zawislak B, McAlister-Henn L, Butow RA: Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell. 2003 Mar;14(3):958-72. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. |
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| 12138751 | Il'chenko AP, Cherniavskaia OG, Shishkanova NV, Finogenova TV: [Metabolism of Yarrowia lipolytica grown on under conditions promoting the production of alpha-ketoglutaric and citric acids: a comparative study of the central metabolism enzymes]. Mikrobiologiia. 2002 May-Jun;71(3):316-22. A comparative study of the enzymes of the tricarboxylic acid (TCA) and cycles in the mutant Yarrowia lipolytica strain N1 capable of producing alpha-ketoglutaric acid (KGA) and showed that almost all enzymes of the TCA cycle are more active under conditions promoting the production of KGA. The activities of malate dehydrogenase, aconitase, -dependent isocitrate dehydrogenase, and fumarase were higher in cells producing KGA than in cells producing |
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| 16232477 | Arikawa Y, Kobayashi M, Kodaira R, Shimosaka M, Muratsubaki H, Enomoto K, Okazaki M: Isolation of sake yeast strains possessing various levels of - and/or -producing abilities by gene disruption or mutation. J Biosci Bioeng. 1999;87(3):333-9. Sake fermented using the aconitase gene (ACO1) disruptant contained a two-fold higher concentration of and a two-fold lower concentration of than that made using the wild-type strain K901. |
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| 16906525 | Mailloux RJ, Hamel R, Appanna VD: Aluminum toxicity elicits a dysfunctional TCA cycle and accumulation in hepatocytes. J Biochem Mol Toxicol. 2006;20(4):198-208. BN-PAGE, SDS-PAGE, and Western blot analyses revealed a marked decrease in activity and expression of succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase-NAD+ (IDH), fumarase (FUM), aconitase (ACN), and cytochrome c oxidase (Cyt C Ox). 13C-NMR and HPLC studies further confirmed the disparate metabolism operative in control and Al-stressed cells and provided evidence for the accumulation of in the latter cultures. |
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| 12948633 | Gerstmeir R, Wendisch VF, Schnicke S, Ruan H, Farwick M, Reinscheid D, Eikmanns BJ: metabolism and its regulation in Corynebacterium glutamicum. J Biotechnol. 2003 Sep 4;104(1-3):99-122. These genes, thus also belonging to the stimulon of C. glutamicum, include genes coding for TCA cycle enzymes (e.g. aconitase and succinate dehydrogenase), for gluconeogenesis (phosphoenolpyruvate carboxykinase), for glycolysis (pyruvate dehydrogenase E1) and genes coding for proteins with hitherto unknown function. |
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| 20353438 | Lemire J, Mailloux R, Auger C, Whalen D, Appanna VD: Pseudomonas fluorescens orchestrates a fine metabolic-balancing act to counter aluminium toxicity. Environ Microbiol. 2010 Mar 25. To counter the Fe conundrum induced by Al toxicity, Pseudomonas fluorescens utilizes lyase and isocitrate dehydrogenase- dependent to metabolize when confronted with an ineffective aconitase provoked by Al stress. |
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| 15158257 | Peng L, Arauzo-Bravo MJ, Shimizu K: Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements. FEMS Microbiol Lett. 2004 Jun 1;235(1):17-23. Some TCA cycle enzymes such as citrate synthase, aconitase and malate dehydrogenase were also upregulated, but enzymes of glycolysis and the pentose phosphate pathway were downregulated. |
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| 19953673 | Kim BJ, Schneider DJ, Cartinhour SW, Shuler ML: Complex responses to culture conditions in Pseudomonas syringae pv. tomato DC3000 continuous cultures: the role of iron in cell growth and virulence factor induction. Biotechnol Bioeng. 2010 Apr 1;105(5):955-64. A reduction in aconitase activity (a TCA cycle enzyme) and ATP levels in iron-limited chemostat cultures was observed compared to iron-supplemented chemostat cultures, indicating that iron affects central metabolic pathways. |
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| 12874354 | Somerville GA, Said-Salim B, Wickman JM, Raffel SJ, Kreiswirth BN, Musser JM: Correlation of catabolism and growth yield in Staphylococcus aureus: implications for host-pathogen interactions. Infect Immun. 2003 Aug;71(8):4724-32. Recently, we reported that the prototypical Staphylococcus aureus strain RN6390 (a derivative of NCTC 8325) had significantly reduced aconitase activity relative to a diverse group of S. aureus isolates, leading to the hypothesis that strain RN6390 has impaired tricarboxylic acid (TCA) cycle-mediated catabolism. |
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| 14559057 | Wlodek D, Gonzales M: Decreased energy levels can cause and sustain obesity. J Theor Biol. 2003 Nov 7;225(1):33-44. The crucial event is the inhibition of the TCA cycle at the step of aconitase. |
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| 15747777 | Dote T, Kono K, Usuda K, Shimizu H, Tanimoto Y, Dote E, Hayashi S: Systemic effects and skin injury after experimental dermal exposure to monochloroacetic acid. Toxicol Ind Health. 2003 Oct;19(7-10):165-9. MCA reportedly enters the TCA cycle and inhibits aconitase. |
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| 17241446 | Shlevin L, Regev-Rudzki N, Karniely S, Pines O: Location-specific depletion of a dual-localized protein. Traffic. 2007 Feb;8(2):169-76. As an example, we fused the yeast tricarboxylic acid (TCA) cycle enzyme aconitase to a degron sequence (SL17) recognizable by the ubiquitin-proteasome system. |
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| 18836533 | Wheatley C: The return of the Scarlet Pimpernel: in inflammation II - cobalamins can both selectively promote all three synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS. J Nutr Environ Med. 2007 Sep;16(3-4):181-211. The up-regulation of transcobalamins [hitherto posited as indicating a central need for (Cbl) in inflammation], whose expression, like inducible synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of (GSCbl), (AdoCbl), may be essential for the timely promotion and later selective inhibition of iNOS and concordant regulation of endothelial and neuronal NOS (eNOS/nNOS.) Cbl may ensure controlled high output of (NO) and its safe deployment, because: (1) Cbl is ultimately responsible for the synthesis or availability of the NOS substrates and cofactors heme, BH (4) / / and via the far-reaching effects of the two Cbl coenzymes, methionine synthase (MS) and methylmalonyl CoA mutase (MCoAM) in, or on, the tricarboxylic acid (TCA) and urea cycles, oxidative phosphorylation, glycolysis and the pentose phosphate pathway. |
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| 14568143 | Makarova KS, Koonin EV: Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysis. FEMS Microbiol Lett. 2003 Oct 10;227(1):17-23. |
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| 19217544 | Gupta P, Ghosalkar A, Mishra S, Chaudhuri TK: Enhancement of over expression and chaperone assisted yield of folded recombinant aconitase in Escherichia coli in bioreactor cultures. J Biosci Bioeng. 2009 Feb;107(2):102-7. |
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| 12548706 | Tabuchi A, Funaji K, Nakatsubo J, Fukuchi M, Tsuchiya T, Tsuda M: Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J Neurosci Res. 2003 Feb 15;71(4):504-15. |
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| 17170147 | Cherkasov AA, Overton RA Jr, Sokolov EP, Sokolova IM: Temperature-dependent effects of cadmium and nucleotides on mitochondrial aconitase from a marine ectotherm, Crassostrea virginica: a role of temperature in oxidative stress and allosteric enzyme regulation. J Exp Biol. 2007 Jan;210(Pt 1):46-55. |
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| 20060926 | Gupta P, Mishra S, Chaudhuri TK: Reduced stability and enhanced surface hydrophobicity drive the binding of apo-aconitase with GroEL during chaperone assisted refolding. Int J Biochem Cell Biol. 2010 May;42(5):683-92. Epub 2010 Jan 9. |
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| 15975908 | Regev-Rudzki N, Karniely S, Ben-Haim NN, Pines O: Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol Biol Cell. 2005 Sep;16(9):4163-71. Epub 2005 Jun 22. |
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| 17525933 | Matheson BK, Adams JL, Zou J, Patel R, Franklin RB: Effect of metabolic inhibitors on ATP and content in PC3 prostate cancer cells. Prostate. 2007 Aug 1;67(11):1211-8. BACKGROUND: In normal prostate epithelial cells low m-aconitase activity decreases oxidation leading to accumulation. |
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| 16252258 | Goncharov NV, Jenkins RO, Radilov AS: Toxicology of fluoroacetate: a review, with possible directions for therapy research. J Appl Toxicol. 2006 Mar-Apr;26(2):148-61. Fluoroacetate (FA; CH2FCOOR) is highly toxic towards humans and other mammals through inhibition of the enzyme aconitase in the tricarboxylic acid cycle, caused by 'lethal synthesis' of an isomer of fluorocitrate (FC). |
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| 19520720 | van Vugt-Lussenburg BM, van der Weel L, Hagen WR, Hagedoorn PL: Identification of two [4Fe-4S]-cluster-containing hydro-lyases from Pyrococcus furiosus. Microbiology. 2009 Sep;155(Pt 9):3015-20. Epub 2009 Jun 11. Nonetheless, its genome encodes more putative TCA cycle enzymes than the closely related Pyrococcus horikoshii and Pyrococcus abyssi, including an aconitase (PF0201). |
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| 12379717 | Somerville GA, Chaussee MS, Morgan CI, Fitzgerald JR, Dorward DW, Reitzer LJ, Musser JM: Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun. 2002 Nov;70(11):6373-82. |
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| 15950872 | Shadel GS: Mitochondrial DNA, aconitase 'wraps' it up. Trends Biochem Sci. 2005 Jun;30(6):294-6. |
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| 15942004 | Lefebre MD, Flannagan RS, Valvano MA: A minor catalase/peroxidase from Burkholderia cenocepacia is required for normal aconitase activity. Microbiology. 2005 Jun;151(Pt 6):1975-85. |
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| 17384188 | Banerjee S, Nandyala AK, Raviprasad P, Ahmed N, Hasnain SE: -dependent RNA-binding activity of Mycobacterium tuberculosis aconitase. J Bacteriol. 2007 Jun;189(11):4046-52. Epub 2007 Mar 23. |
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| 19526285 | Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK: Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotox Res. 2009 Oct;16(3):186-93. Epub 2009 Mar 5. MAO-B mediated increases in H (2) O (2) also appeared to result in direct oxidative inhibition of both mitochondrial complex I and aconitase. |
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| 17020548 | Denayer S, Matthijs S, Cornelis P: Resistance to in Pseudomonas fluorescens ATCC 17400 caused by mutations in TCA cycle enzymes. FEMS Microbiol Lett. 2006 Nov;264(1):59-64. The second mutant had the transposon inserted into acnD, one out of three genes coding for a 2-methyl- dehydratase (aconitase). |
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| 17084901 | Theil EC: Integrating iron and /antioxidant signals via a combinatorial array of DNA - (antioxidant response elements) and mRNA (iron responsive elements) sequences. J Inorg Biochem. 2006 Dec;100(12):2074-8. Epub 2006 Sep 23. Fe (cellular iron), O (dioxygen, antioxidant inducers, peroxide), and P (protein phosphorylation) signals combine to regulate DNA activity (transcription/mRNA synthesis) for antioxidant/Phase II response proteins (e.g., ferritin H, ferritin L, thioredoxin reductase I, NAD (P) H oxido-reductase, heme oxygenase1 and beta-globin) and mRNA activity for proteins of iron transport, storage or metabolism (e.g., ferritin H, ferritin L, transferrin receptor1, ferroportin, mt-aconitase-TCA cycle and synthase - heme biosynthesis). |
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