Protein Information

Name brain derived neurotrophic factor
Synonyms Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
18433734 Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I: Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008 May 23;1211:37-43. Epub 2008 Mar 21.

7(0,0,0,7) Details
12548706 Tabuchi A, Funaji K, Nakatsubo J, Fukuchi M, Tsuchiya T, Tsuda M: Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J Neurosci Res. 2003 Feb 15;71(4):504-15.


Suppression of the apoptosis of CGCs mediated by the Ca (2+) influx or neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and adenylate cyclase activating polypeptide-38 (PACAP-38) attenuated the aconitase inactivation as well as the lactate dehydrogenase (LDH)-release and the decrease in MTT reduction.
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12422559 Bourin M, David DJ, Jolliet P, Gardier A: [Mechanism of action of antidepressants and therapeutic perspectives] . Therapie. 2002 Jul-Aug;57(4):385-96.


Indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various G proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (BDNF).
1(0,0,0,1) Details