Protein Information

Name NADH dehydrogenase
Synonyms B14.5b; NADH dehydrogenase; CI B14.5b; Complex I B14.5b; HLC 2; HLC2; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH ubiquinone oxidoreductase subunit B14.5b…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
12557308 Yoon SH, Han MJ, Lee SY, Jeong KJ, Yoo JS: Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture. Biotechnol Bioeng. 2003 Mar 30;81(7):753-67.


The expression of genes of TCA cycle enzymes, NADH dehydrogenase and ATPase, was up-regulated during the exponential fed-batch period and was down-regulated afterward.
1(0,0,0,1) Details
14604472 Arathi G, Sachdanandam P: Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J Pharm Pharmacol. 2003 Sep;55(9):1283-90.


The activities of mitochondrial enzymes isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH-dehydrogenase and cytochrome C oxidase were significantly lowered in mammary carcinoma-bearing rats when compared with control rats.
1(0,0,0,1) Details
16786185 Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T: Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007 Jan;294(1-2):55-63. Epub 2006 Jun 20.


Adriamycin (2.5 mg/kg body wt., i.p.) induced mitochondrial damage in rats was assessed in terms of decreased activities (p <0.05) of cardiac marker enzymes (lactate dehydrogenase, creatine phosphokinase, amino transferases), TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase, respiratory marker enzymes (NADH-dehydrogenase, cytochrome-C-oxidase), mitochondrial antioxidant enzymes (GPx, GSH, SOD,CAT) and increased (p <0.05) level of lipid peroxidation.
1(0,0,0,1) Details
20078895 Butler JE, Young ND, Lovley DR: Evolution of electron transfer out of the cell: comparative genomics of six Geobacter genomes. BMC Genomics. 2010 Jan 17;11:40.


An NADH dehydrogenase, the ATP synthase, and several TCA cycle enzymes were among the best conserved in the genomes.
1(0,0,0,1) Details
16413626 Mohankumar K, Ramasamy P: Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. Virus Res. 2006 Jun;118(1-2):130-5. Epub 2006 Jan 18.


The activities of membrane bound phosphatases (Na (+) K (+) ATPase, Ca (2+) ATPase, Mg (2+) ATPase and Total ATPase), transaminases (alanine transaminase (ALT) and aspartate transaminase (AST)) and mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), alpha-ketoglutarate dehydrogenase (KGDH), NADH dehydrogenase, cytochrome C oxidase) in WSSV-infected tissues (hemolymph, hepatopancreas, gills and muscle) of Fenneropenaeus indicus were determined at intervals after WSSV infection (0, 24, 48, 72 and after 72 h (moribund)).
1(0,0,0,1) Details
18644460 Izallalen M, Mahadevan R, Burgard A, Postier B, Didonato R Jr, Sun J, Schilling CH, Lovley DR: Geobacter sulfurreducens strain engineered for increased rates of respiration. Metab Eng. 2008 Sep;10(5):267-75. Epub 2008 Jun 27.


Genome-wide analysis of gene transcript levels indicated that when the higher rate of respiration was induced transcript levels were higher for genes involved in energy metabolism, especially in those encoding TCA cycle enzymes, subunits of the NADH dehydrogenase, and proteins involved in electron acceptor reduction.
1(0,0,0,1) Details
17574827 Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan R: Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):349-55. Epub 2007 Jun 15.


The dietary supplementation of 2% squalene significantly minimized aging associated alterations in mitochondrial energy status by maintaining the activities of TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase) and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at higher level in the liver mitochondria of aged rats compared with unsupplemented controls.
1(0,0,0,1) Details