Protein Information

Name bile salt export pump
Synonyms ABC16; ABCB11; ATP binding cassette sub family B member 11; BSEP; Bile salt export pump; PFIC 2; PFIC2; PGY 4…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
15901796 Hirano M, Maeda K, Hayashi H, Kusuhara H, Sugiyama Y: Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.

6(0,0,0,6) Details
17409513 Iwanaga T, Nakakariya M, Yabuuchi H, Maeda T, Tamai I: Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis. Biol Pharm Bull. 2007 Apr;30(4):739-44.

2(0,0,0,2) Details
12967592 Elamiri A, Perwaiz S, Tuchweber B, Yousef IM: Effect of mdr2 mutation with combined tandem disruption of canalicular glycoprotein transporters by cyclosporine A on bile formation in mice. Pharmacol Res. 2003 Nov;48(5):467-72.


Secondly, mutation in the bile salt exporting pump (BSEP)/sister of P-glycoprotein (spgp) gene causes progressive familial intrahepatic cholestasis type 2 in human.
1(0,0,0,1) Details
15280219 Takada T, Weiss HM, Kretz O, Gross G, Sugiyama Y: Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug Metab Dispos. 2004 Nov;32(11):1272-8. Epub 2004 Jul 27.


The effect of PKI166 and ACU154 on transport of [3H] estradiol-17beta-d-glucuronide (EG; via mrp2/MRP2 and OATP2) or [3H] taurocholic acid (TCA; via bile salt export pump (bsep) was analyzed.
1(0,0,0,1) Details