Protein Information

Name alcohol dehydrogenase (protein family or complex)
Synonyms ADH; alcohol dehydrogenase; alcohol dehydrogenases

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16233574 Chinnawirotpisan P, Theeragool G, Limtong S, Toyama H, Adachi OO, Matsushita K: Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108. J Biosci Bioeng. 2003;96(6):564-71.

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18435559 Matsuzaki F, Shimizu M, Wariishi H: Proteomic and metabolomic analyses of the white-rot fungus Phanerochaete chrysosporium exposed to exogenous benzoic acid. J Proteome Res. 2008 Jun;7(6):2342-50. Epub 2008 Apr 25.

Up-regulation of aryl-alcohol dehydrogenase, arylaldehyde dehydrogenase, and cytochrome P450s was observed upon addition of exogenous BA, suggesting that these enzymes play key roles in its metabolism.
Intracellular metabolic shifts from the short-cut TCA/glyoxylate bicycle system to the TCA cycle and an increased flux in the TCA cycle indicated activation of the heme biosynthetic pathway and the production of NAD (P) H.
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16127727 Gade D, Gobom J, Rabus R: Proteomic analysis of carbohydrate catabolism and regulation in the marine bacterium Rhodopirellula baltica. Proteomics. 2005 Sep;5(14):3672-83.


For only some of the regulated proteins, the coding genes are located in a physiologically meaningful genomic context. e.g., a ribose-induced alcohol dehydrogenase is encoded within an operon-like structure together with genes coding for a ribose-specific ABC-transporter.
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18951774 Ewaze JO, Summerbell RC, Scott JA: Ethanol physiology in the warehouse-staining fungus, Baudoinia compniacensis. Mycol Res. 2008 Nov;112(Pt 11):1373-80. Epub 2008 May 18.


We found that ethanol was catabolized into central metabolism via alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH).
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17500021 Cordier H, Mendes F, Vasconcelos I, Francois JM: A metabolic and genomic study of engineered Saccharomyces cerevisiae strains for high glycerol production. Metab Eng. 2007 Jul;9(4):364-78. Epub 2007 Apr 7.


Further deletion of ADH1 and overexpression of ALD3, encoding, respectively, the major NAD+-dependent alcohol dehydrogenase and a cytosolic NAD+-dependent aldehyde dehydrogenase yielded a yeast strain able to produce 0.46 g glycerol (g glucose)(-1) at a maximal rate of 3.1 mmol (g dry mass)(-1) h (-1) in aerated batch cultures.
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18533529 Kang YY, Guo SR, Duan JJ: [Effects of root zone hypoxia on respiratory metabolism of cucumber seedlings roots]. Ying Yong Sheng Tai Xue Bao. 2008 Mar;19(3):583-7.


Under root zone hypoxia stress, the decrement of succinic dehydrogenase (SDH) and isocitric dehydrogenase (IDH) activities and the increment of lactate dehydrogenase (LDH) activity and lactate and pyruvate contents were lesser in Lubachun No. 4 than in Zhongnong No. 8 seedlings roots, but conversely, the increment of pyruvate decarboxylase (PDC) and alcohol dehydrogenase (ADH) activities and alcohol and alanine contents in Lubachun No. 4 seedlings roots were higher than those in Zhongnong No. 8 seedlings roots.
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15953580 Natarajan S, Xu C, Caperna TJ, Garrett WM: Comparison of protein solubilization methods suitable for proteomic analysis of soybean seed proteins. Anal Biochem. 2005 Jul 15;342(2):214-20.


The proteins identified were beta-conglycinin, glycinin, Kunitz trypsin inhibitor, alcohol dehydrogenase, Gly m Bd 28K allergen, and sucrose binding proteins.
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