Protein Information

Name ICAM 1
Synonyms BB2; CD54; CD54 antigen; ICAM 1; ICAM1; Intercellular adhesion molecule 1; Intercellular adhesion molecule 1 precursor; Major group rhinovirus receptor…

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
19338585 An S, Kim S, Huh Y, Lee TR, Kim HK, Park KL, Eun HC: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. Contact Dermatitis. 2009 Apr;60(4):185-92.

METHODS: We investigated the expression of CD54, CD86, CD83, CD80, and CD40 after a 1-day exposure to sensitizers (1-chloro-2,4-dinitrobenzene; 2,4-dinitrofluorobenzene; benzocaine; 5-chloro-2-methyl-4-isothiazolin-3-one; hexyl cinnamic aldehyde; eugenol; nickel sulfate hexahydrate; potassium dichromate; cobalt sulfate; 2-mercaptobenzothiazole; and ammonium tetrachloroplatinate) and non-sensitizers (sodium lauryl sulfate, benzalkonium chloride, lactic acid, salicylic acid, isopropanol, and dimethyl sulphoxide).
8(0,0,1,3) Details
16900358 Pauly A, Brignole-Baudouin F, Guenoun JM, Riancho L, Rat P, Warnet JM, Baudouin C: Comparative study of topical anti-allergic eye drops on human conjunctiva-derived cells: responses to histamine and IFN gamma and toxicological profiles. Graefes Arch Clin Exp Ophthalmol. 2007 Apr;245(4):534-46. Epub 2006 Aug 10.

Supernatants of histamine-stimulated cells were evaluated for the production of IL-6 and IL-8 by ELISA, while the expression of ICAM-1 was evaluated by flow cytometry on IFN gamma-stimulated cells.
Conversely, eye drops preserved with benzalkonium chloride (BAC) induced even higher ICAM-1 expression levels on IFN gamma-stimulated cells than did IFN gamma alone, whereas unpreserved drugs had no effect.
3(0,0,0,3) Details
9394834 Aiba S, Terunuma A, Manome H, Tagami H: Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol. 1997 Nov;27(11):3031-8.

In spite of the augmented CD86 expression on DC treated with DNCB or NiCl2, these chemicals induced different responses of DC in their expression of CD54 and HLA-DR and the production of IL-6 and tumor necrosis factor (TNF)-alpha.
After we confirmed that monocyte-derived DC showed at least phenotypic characteristics and a response to TNF-alpha similar to LC, we added various chemicals, i.e., dinitrochlorobenzene (DNCB), trinitrochlorobenzene (TNCB), NiCl2, ZnCl2, sodium dodecyl sulfate (SDS), or benzalkonium chloride (BC), to a culture of purified monocyte-derived CD1a+ DC.
1(0,0,0,1) Details
19760156 Guzman-de la Garza FJ, Camara-Lemarroy CR, Ballesteros-Elizondo RG, Alarcon-Galvan G, Cordero-Perez P, Fernandez-Garza NE: Ketamine and the Myenteric Plexus in Intestinal Ischemia/Reperfusion Injury. Dig Dis Sci. 2009 Sep 16.

METHODS: Rats were divided into six groups: sham, IR (30 min ischemia/60 min reperfusion), KET+IR (50 mg/kg i.p. ketamine injection before I/R), DEN (myenteric plexus ablated with benzalkonium chloride (BAC) and sham operation performed), DEN+IR (BAC treated and I/R induced), and DEN+KET+IR (BAC treated, ketamine administered, and I/R induced).
Serum concentrations of p-selectin, intracellular adhesion molecule-1 (ICAM-1), and antithrombin III (ATIII) were measured, and tissue samples were obtained for histological analysis.
2(0,0,0,2) Details
13130254 Pisella PJ, Lala E, Parier V, Brignole F, Baudouin C: [Effect of preservatives on the conjunctiva: a comparative study of beta-blocker eye drops with and without preservatives in glaucoma patients]. J Fr Ophtalmol. 2003 Sep;26(7):675-9.


Specimens were analyzed by flow cytometry for inflammatory profile (using antibodies directed against HLA DR and ICAM-1) and mucin detection (anti-M1/MUC5AC antibody).
2(0,0,0,2) Details
19168896 Pauly A, Meloni M, Brignole-Baudouin F, Warnet JM, Baudouin C: Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1644-52. Epub 2009 Jan 24.

Frozen sections were analyzed by using fluorescence confocal microscopy for the presence of TUNEL, activated caspase-3, Ki67, ICAM-1, HLA-DR, E-cadherin, and occludin.
2(0,0,0,2) Details
15980234 Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F: In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2444-50.


Expressions of three inflammation- and immune-related markers, intercellular adhesion molecule (ICAM)-1, platelet-endothelial cell adhesion molecule (PECAM)-1 and HLA DR, were evaluated with flow cytometry after 24 to 72 hours of contact at low, subtoxic concentrations.
1(0,0,0,1) Details
15111589 Pisella PJ, Debbasch C, Hamard P, Creuzot-Garcher C, Rat P, Brignole F, Baudouin C: Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest Ophthalmol Vis Sci. 2004 May;45(5):1360-8.


Expression of HLA-DR, intercellular adhesion molecule (ICAM)-1, and mucin was evaluated in a masked manner by flow cytometry.
1(0,0,0,1) Details