| 16426572 |
Zhang ZY, Pelletier RD, Wong YN, Sugawara M, Zhao N, Littlefield BA: Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):399-407. Epub 2006 Jan 11.
Moreover, while both genes were up-regulated by TCDD in primary hepatocytes and HepG2 cells, the induction of CYP1A1 and CYP1A2 at the mRNA level was distinguishable, indicated by the marked differences in activation kinetics and the response to the protein synthesis inhibitors, anisomycin and cycloheximide. |
32(0,1,1,2) |
Details |