| Name | cyclin E |
|---|---|
| Synonyms | CCNE; CCNE 1; CCNE1; Cyclin E; Cyclin E1; Cyclin Es; Cyclin Et; G1/S specific cyclin E1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16411808 | Engbers-Buijtenhuijs P, Buttafoco L, Poot AA, Geelkerken RH, Feijen J, Vermes I: Analysis of the balance between proliferation and apoptosis of cultured vascular smooth muscle cells for tissue-engineering applications. Tissue Eng. 2005 Nov-Dec;11(11-12):1631-9. Human vascular smooth muscle cells (VSMCs) were cultured either on gelatin-coated tissue culture polystyrene or in three-dimensional porous scaffolds composed of insoluble collagen and elastin. mRNA concentrations of cyclin E, as a marker of proliferation, and of tissue transglutaminase (tTG) as a marker of apoptosis, quantified by a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and normalized to porphobilinogen deaminase mRNA concentrations, were analyzed. tTG mRNA expression levels were increased when apoptosis was induced by tumor necrosis factor-alpha in combination with cycloheximide or by culturing the cells in serum-free culture medium. |
7(0,0,1,2) | Details |
| 16201272 | Xie D, Feng Y, Wu J, Liu S, Li X, Tao D, Gong J: Standard and quantitative analysis of cyclin E threshold by cyclin E/DNA multiparameter flow cytometry. J Huazhong Univ Sci Technolog Med Sci. 2005;25(3):282-4. Additionally, cyclin E was detected in cells which were treated with and cycloheximide (CHX) under the same PMT voltage. |
15(0,0,1,10) | Details |
| 17545210 | Lehmann GM, McCabe MJ Jr: Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription. Toxicol Sci. 2007 Sep;99(1):70-8. Epub 2007 Jun 1. Cdc25A dual specificity phosphatase controls entry into and progression through S phase by dephosphorylating sites of inhibitory phosphorylation on cyclin E-cdk2 (Thr14 and Tyr15). However, cycloheximide half-life assay reveals that cdc25A is actually stabilized in arsenite-treated cells. |
2(0,0,0,2) | Details |
| 15735718 | He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J: Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr 21;24(18):2929-43. The induced p21 binds to both the Cdk4/cyclin D and Cdk2/cyclin E complexes and inhibits both of their kinase activities. Conversely, inhibition of p21 induction by cycloheximide or by p21 gene deletion prevents DAP-induced inhibition of Cdk4 and Cdk2 activities. |
1(0,0,0,1) | Details |
| 15964852 | Zhu H, Nie L, Maki CG: Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif. J Biol Chem. 2005 Aug 12;280(32):29282-8. Epub 2005 Jun 17. In the current report, co-expression with cyclin E and Cdk2 stabilized p21 in a manner that required the CDK-binding site of p21 and a cyclin-binding site (cy1) located in the p21 N terminus. |
1(0,0,0,1) | Details |