| Name | NMDA receptor (protein family or complex) |
|---|---|
| Synonyms | Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15033007 | Dai XF, Zhou ZJ, Gu XA, Sun YG, Zheng G, Zheng J: [Protective effect of memantine on N-methyl-D-aspartate receptor in dichlorvos-poisoned rat brain]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):11-4. Lower level of memantine (5 and 25 mg/kg) could antagonize the dichlorvos-evoked down-regulation of [(3) H] MK-801 binding to NMDA receptor in rat brain [Bmax value: (0.55 +/- 0.07) and (0.64 +/- 0.07) pmol/mg pro; Kd value: (38.68 +/- 4.54) and (32.58 +/- 3.90) nmol/L respectively] while higher dose of memantine (45 mg/kg), the Bmax (0.45 +/- 0.06) pmol/mg pro and Kd (22.88 +/- 4.42) nmol/L of NMDA receptor were significantly decreased (P < 0.01). |
181(1,4,5,6) | Details |
| 15824473 | Zhou Z, Dai X, Gu X, Sun Y, Zheng G, Zheng J: Memantine alleviates toxicity induced by dichlorvos in rats. J Occup Health. 2005 Mar;47(2):96-101. Dichlorvos evoked down-regulation of the affinity and density of [(3) H] MK-801 binding to NMDA receptor in the brain of rats receiving dichlorvos (15 and 25 mg/kg bw, i.p.). |
127(1,2,4,7) | Details |
| 1533269 | Johnson PS, Michaelis EK: Characterization of organophosphate interactions at N-methyl-D-aspartate receptors in brain synaptic membranes. Mol Pharmacol. 1992 Apr;41(4):750-6. Diisopropylfluorophosphate (DFP), dichlorvos, cyanophos, mipafox, and o-ethyl o- phenylphosphonothioate are relatively potent inhibitors of [3H] CPP binding to synaptic membranes. |
4(0,0,0,4) | Details |
| 17157343 | Dekundy A, Kaminski RM, Zielinska E, Turski WA: antagonists exert distinct effects in experimental organophosphate or poisoning in mice. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):114-21. Epub 2006 Nov 6. The data indicate that both muscarinic and NMDA receptor-mediated mechanisms contribute to the acute toxicity of AChE inhibitors, and NMDA receptors seem critical to OP-induced seizures. In the present study, the effects of dizocilpine (MK-801, 1 mg/kg) or 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP, 10 mg/kg), alone or combined with muscarinic antagonist atropine (1.8 mg/kg), on convulsant and lethal properties of an OP pesticide dichlorvos or a drug physostigmine, were studied in mice. |
1(0,0,0,1) | Details |
| 12660363 | Dekundy A, Kaminski RM, Turski WA: Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice. Toxicol Sci. 2003 Apr;72(2):289-95. With respect to the mechanism underlying anticholinesterase-induced neurotoxicity, muscarinic and nicotinic, as well as NMDA receptors, seem to play major roles. Mice were administered anticholinesterase pesticides dichlorvos (DDVP) or methomyl (MET). |
1(0,0,0,1) | Details |