Protein Information

Name Ghrelin
Synonyms Appetite regulating hormone; Appetite regulating hormone precursor; GHRL; Ghrelin; Growth hormone releasing peptide; Growth hormone secretagogue; M46 protein; MTLRP…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16887908 Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y: Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Endocrinology. 2006 Nov;147(11):5102-9. Epub 2006 Aug 3.

The stimulatory effects of ghrelin on NPY gene expression were abolished in the presence of cycloheximide, which blocks translation, suggesting that de novo protein synthesis is required for ghrelin action.
87(1,1,1,7) Details
16493119 Giovambattista A, Piermaria J, Suescun MO, Calandra RS, Gaillard RC, Spinedi E: Direct effect of ghrelin on leptin production by cultured rat white adipocytes. Obesity (Silver Spring). 2006 Jan;14(1):19-27.

Adipocytes were also incubated with ghrelin and inhibitors either of RNA (actinomycin D) or protein synthesis (cycloheximide) or with several concentrations (10 to 1000 nM) of a specific ghrelin antagonist.
37(0,1,1,7) Details
19223651 Dominguez B, Felix R, Monjaraz E: Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes. Am J Physiol Endocrinol Metab. 2009 May;296(5):E1148-56. Epub 2009 Feb 17.

2(0,0,0,2) Details