| Name | brain derived neurotrophic factor |
|---|---|
| Synonyms | Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18729634 | McGauran AM, Moore JB, Madsen D, Barry D, O'Dea S, Mahon BP, Commins S: A possible role for protein synthesis, extracellular signal-regulated kinase, and brain-derived neurotrophic factor in long-term spatial memory retention in the water maze. Behav Neurosci. 2008 Aug;122(4):805-15. BDNF and ERK expression was also down-regulated in animals injected with this dose of cycloheximide. |
10(0,0,1,5) | Details |
| 18501512 | Imbesi M, Uz T, Dzitoyeva S, Manev H: Stimulatory effects of a receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells. Neurosci Lett. 2008 Jul 4;439(1):34-6. Epub 2008 May 2. However, it was prevented by treatment of cultures with a protein synthesis inhibitor cycloheximide. |
7(0,0,0,7) | Details |
| 17404514 | Simpson PJ, Moon C, Kleman AM, Connolly E, Ronnett GV: Progressive and inhibitory cell cycle proteins act simultaneously to regulate neurotrophin-mediated proliferation and maturation of neuronal precursors. Cell Cycle. 2007 May 2;6(9):1077-89. Epub 2007 May 7. |
6(0,0,0,6) | Details |
| 16176349 | Elliott E, Atlas R, Lange A, Ginzburg I: Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism. Eur J Neurosci. 2005 Sep;22(5):1081-9. |
4(0,0,0,4) | Details |
| 19923273 | Baumbauer KM, Huie JR, Hughes AJ, Grau JW: Timing in the absence of supraspinal input II: regularly spaced stimulation induces a lasting alteration in spinal function that depends on the NMDA receptor, BDNF release, and protein synthesis. J Neurosci. 2009 Nov 18;29(46):14383-93. Administration of the protein synthesis inhibitor cycloheximide after training blocked the long-term effect. |
2(0,0,0,2) | Details |
| 17045260 | Orozco C, Garcia-de-Diego AM, Arias E, Hernandez-Guijo JM, Garcia AG, Villarroya M, Lopez MG: Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death. Eur J Pharmacol. 2006 Dec 28;553(1-3):28-38. Epub 2006 Sep 12. Preconditioning with K (+) or TEA increased by 2.5-fold the expression of brain-derived neurotrophic factor and by nearly 2-fold the expression of the antiapoptotic protein Bcl-2. |
2(0,0,0,2) | Details |
| 16034370 | Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M: Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab. 2006 Feb;26(2):199-208. In a neuronal-glial cell coculture, preexposure to xenon for 2 h caused a concentration-dependent reduction of lactate dehydrogenase release from cells deprived of and 24 h later; xenon's preconditioning effect was abolished by cycloheximide, a protein synthesis inhibitor. Also, the prosurvival proteins Bcl-2 and brain-derived neurotrophic factor were upregulated by xenon treatment. |
1(0,0,0,1) | Details |
| 16000155 | Kramer D, Caruso A, Nicoletti F, Genazzani AA: Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation. J Neurochem. 2005 Sep;94(5):1374-83. Epub 2005 Jul 5. Furthermore, calcineurin activation reciprocally regulates the expression of brain-derived neurotrophic factor, bdnf, and its receptor trkb, which have also been shown to play a role in neuronal migration. |
1(0,0,0,1) | Details |
| 15870071 | Vargas MR, Pehar M, Cassina P, Martinez-Palma L, Thompson JA, Beckman JS, Barbeito L: Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005 Jul 8;280(27):25571-9. Epub 2005 May 3. FGF-1 induced the expression of HO-1 in cultured rat spinal cord astrocytes, which was dependent on FGF receptor activation and prevented by cycloheximide. Overexpression of Nrf2 in astrocytes increased survival of co-cultured embryonic motor neurons and prevented motor neuron apoptosis mediated by nerve growth factor through p75 neurotrophin receptor. |
1(0,0,0,1) | Details |
| 17287525 | Ramos A, Ho WC, Forte S, Dickson K, Boutilier J, Favell K, Barker PA: Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. J Neurosci. 2007 Feb 7;27(6):1498-506. Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized. |
1(0,0,0,1) | Details |
| 18315559 | Kalita K, Makonchuk D, Gomes C, Zheng JJ, Hetman M: Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem. 2008 Mar 18. The protein synthesis inhibitor cycloheximide blocked apoptosis that was induced by over-expressed shTIF-IA or active form of p53. |
0(0,0,0,0) | Details |