Protein Information

Name prion protein
Synonyms ASCR; PRIP; PRP; PRNP; Prion related protein; CD230; CD230 antigen; CJD…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
19383478 Hyde JS, Bennett B, Walter ED, Millhauser GL, Sidabras JW, Antholine WE: EPR of Cu2+ prion protein constructs at 2 GHz using the g (perpendicular) region to characterize nitrogen ligation. Biophys J. 2009 Apr 22;96(8):3354-62.

A double octarepeat prion protein construct, which has two histidines, mixed with copper sulfate in a 3:2 molar ratio provides at most three imidazole ligands to each copper ion to form a square-planar Cu (2+) complex.
33(0,1,1,3) Details
14713301 Morot-Gaudry-Talarmain Y, Rezaei H, Guermonprez L, Treguer E, Grosclaude J: Selective prion protein binding to synaptic components is modulated by oxidative and nitrosative changes induced by copper (II) and peroxynitrite in cholinergic synaptosomes, unveiling a role for calcineurin B and thioredoxin. J Neurochem. 2003 Dec;87(6):1456-70.

4(0,0,0,4) Details
9411764 Barinaga M: Protective role for prion protein? Science. 1997 Nov 21;278(5342):1404-5.

1(0,0,0,1) Details
19678548 Kagenishi T, Yokawa K, Kuse M, Isobe M, Bouteau F, Kawano T: Prevention of copper-induced calcium influx and cell death by prion-derived peptide in suspension-cultured tobacco cells. Z Naturforsch C. 2009 May-Jun;64(5-6):411-7.


Impact of copper on the oxidative and calcium signal transductions leading to cell death in plant cells and the effects of the copper-binding peptide derived from the human prion protein (PrP) as a novel plant-protecting agent were assessed using a cell suspension culture of transgenic tobacco (Nicotiana tabacum L., cell line BY-2) expressing the aequorin gene.
1(0,0,0,1) Details