Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name oxytetracycline
CAS

Reference List

PubMed Abstract RScore(About this table)
16635103 Pari L, Gnanasoundari M: Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol. 2006 May;98(5):456-61.

Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver.
87(1,1,2,2) Details
10613865 Avery SV, Malkapuram S, Mateus C, Babb KS: Copper/zinc-Superoxide dismutase is required for oxytetracycline resistance of Saccharomyces cerevisiae. J Bacteriol. 2000 Jan;182(1):76-80.
6(0,0,1,1) Details
17050244 Gnanasoundari M, Pari L: Impact of naringenin on oxytetracycline-mediated oxidative damage in kidney of rats. Ren Fail. 2006;28(7):599-605.

A significant increase in lipid peroxidation markers (TBARS and lipid hydroperoxide) and decrease in antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and low molecular weight antioxidants (vitamin C, vitamin E, and reduced glutathione) levels were also observed in oxytetracycline-treated rats.
6(0,0,1,1) Details
12897486 Topsakal C, Kilic N, Ozveren F, Akdemir I, Kaplan M, Tiftikci M, Gursu F: Effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant defense system, paraoxonase (PON1) activities, and homocysteine levels in an animal model of spinal cord injury. Spine (Phila Pa 1976). 2003 Aug 1;28(15):1643-52.

Spinal cord tissue and blood malonyldialdehyde and plasma homocysteine levels, plasma glutathione peroxidase, superoxide dismutase, paraoxonase activities were assayed.
3(0,0,0,3) Details
3034858 Martin JP Jr, Colina K, Logsdon N: Role of oxygen radicals in the phototoxicity of tetracyclines toward Escherichia coli B. J Bacteriol. 1987 Jun;169(6):2516-22.

The rate of reduction was dependent on the tetracycline concentration and on the derivative being examined, with doxycycline greater than or equal to demeclocycline greater than tetracycline greater than oxytetracycline.
Tetracycline-mediated cytochrome c reduction was oxygen dependent and inhibited up to 70% by superoxide dismutase.
3(0,0,0,3) Details
11557497 Angrave FE, Avery SV: Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics. Antimicrob Agents Chemother. 2001 Oct;45(10):2939-42.


Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC).
2(0,0,0,2) Details
3039994 Li AS, Roethling HP, Cummings KB, Chignell CF: O2- photogenerated from aqueous solutions of tetracycline antibiotics (pH 7.3) as evidenced by DMPO spin trapping and cytochrome c reduction. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1191-5.

UV-irradiation of several tetracycline antibiotics in aqueous buffer (pH 7.3) resulted in the generation of the superoxide anion radical (O2-) which was detected by cytochrome c reduction and by spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide and was inhibited by superoxide dismutase.
A comparison of the O2- yields from the tetracyclines examined showed the trend chlortetracycline (CTC) greater than oxytetracycline (OXY) greater than demeclocycline (DEM) much greater than (doxycycline (DOXY) = tetracycline (TC) = minocycline (MINO) = 0).
1(0,0,0,1) Details
15105154 Avery AM, Goddard HJ, Sumner ER, Avery SV: Iron blocks the accumulation and activity of tetracyclines in bacteria. Antimicrob Agents Chemother. 2004 May;48(5):1892-4.


The effect of Fe was independent of superoxide dismutase activity and of intracellular Fe, but accumulation of tetracyclines was blocked in high-Fe medium.
1(0,0,0,1) Details
14647012 Sapmaz E, Ayar A, Celik H, Sapmaz T, Kilic N, Yasar MA: Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. Neuro Endocrinol Lett. 2003 Oct;24(5):350-4.

Ovarian tissue and blood malondialdehyde (MDA) levels, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) levels were determined.
1(0,0,0,1) Details