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oxytetracycline

Identification (Source:EPA,EU)

ID	355
Name	oxytetracycline
CAS	79-57-2
IUPAC
Inchi	InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
CIPAC	316
EPA Code
Formula	C22H24N2O9
SMILES	O=C4\C2=C(/O)c1c(cccc1O)[C@](O)(C)[C@H]2[C@H](O)[C@@H]3[C@@]4(O)C(=O)/C(C(=O)[C@H]3N(C)C)=C(\O)N
Status	Not Approved

Classification

Mode of Action	Broad spectrum, protein synthesis inhibitor
Pesticide Type	Bactericide, Antimicrobial, Veterinary treatment
Chemical Group	Micro-organism derived
Classification	Bactericides

Properties (Source:PubChem)

Molecular Weight	460.44
Physical State	Yellow crystalline powder
AlogP	-1.586
H-Bond Donor	7
H-Bond Acceptor	11
Surface Area	434.89
Polar Surface Area	201.85

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	0.183 mg l-1
Algae	Acute	72 hour	EC50, growth	0.342 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	46.2 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	102 mg l-1
Birds	Acute		LD50	> 5620 mg kg-1
Birds	Acute		LD50	> 5620 mg kg-1
Earthworms	Acute	14 day	LD50	1954 mg kg-1
Fish	Acute	96 hour	LC50	116 mg l-1
Honeybees	Acute	48 hour	LD50	100 μg bee-1
Mammals	Acute oral		LD50	> 4800 mg kg-1
Mammals	Acute oral		LD50	> 4800 mg kg-1
	Bio-concentration factor		BCF	0.6
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	0.6
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
superoxide dismutase	110(1,1,4,15)	Details
catalase	97(1,1,3,7)	Details
Ca II	89(1,1,2,4)	Details
glycogen phosphorylase	87(1,1,2,2)	Details
lysozyme	87(1,1,1,7)	Details
P glycoprotein	85(1,1,1,5)	Details
gelatinases	83(1,1,1,3)	Details
somatotropins	82(1,1,1,2)	Details
Tetran	82(1,1,1,2)	Details
Cytochrome c oxidase (protein family or complex)	82(1,1,1,2)	Details
glyoxalase I	81(1,1,1,1)	Details
phosphofructokinase	81(1,1,1,1)	Details
glycolytic enzymes	81(1,1,1,1)	Details
C18	112(0,1,9,42)	Details
glycogen synthase	44(0,1,3,4)	Details
lactate dehydrogenase (protein family or complex)	44(0,1,3,4)	Details
K12	39(0,1,2,4)	Details
per 1	31(0,1,1,1)	Details
all 1	31(0,1,1,1)	Details
TL1	31(0,1,1,1)	Details
alkaline phosphatase	28(0,0,4,8)	Details
Ot r	25(0,0,2,15)	Details
Paraoxonase	21(0,0,3,6)	Details
muscles	20(0,0,2,10)	Details
PFGE	20(0,0,1,15)	Details
albumin	14(0,0,0,14)	Details
matrix metalloproteinase 1	12(0,0,2,2)	Details
RP2	11(0,0,1,6)	Details
RP3	11(0,0,1,6)	Details
haptoglobin	10(0,0,0,10)	Details
Substance P	10(0,0,1,5)	Details
glucose 6 phosphate dehydrogenase	9(0,0,1,4)	Details
S12	9(0,0,1,4)	Details
G6PD	9(0,0,1,4)	Details
basic fibroblast growth factor	8(0,0,0,8)	Details

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