Protein Information

Name connective tissue growth factor
Synonyms CCN 2; CCN2; CTGF; Connective tissue growth factor; Connective tissue growth factor precursor; FISP 12 protein; HCS24; Hypertrophic chondrocyte specific protein 24…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
20035857 Tung JN, Lang YD, Wang LF, Chen CM: Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicol In Vitro. 2010 Apr;24(3):803-8. Epub 2009 Dec 24.

The aims of this study were to investigate the effects of paraquat on ANG II, ANG II receptors, CTGF, and collagen expressions and to assess the role of ANG II receptors in paraquat-induced collagen synthesis in human lung fibroblasts (MRC-5).
126(1,2,4,6) Details
16767377 Matsuda S, Gomi F, Katayama T, Koyama Y, Tohyama M, Tano Y: Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. Jpn J Ophthalmol. 2006 May-Jun;50(3):229-34.

Using paraquat, both CTGF mRNA and protein were upregulated by five doses of paraquat.
14(0,0,1,9) Details
15728566 Matsuda S, Gomi F, Oshima Y, Tohyama M, Tano Y: Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1062-8.

METHODS: TA (10 nM, 1 microM, or 100 microM) was added to ARPE19 cells exposed to oxidative stress induced by hypoxia-reoxygenation and paraquat.
7(0,0,0,7) Details