Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
8400082 Keane WF, O'Donnell MP, Kasiske BL, Kim Y: Oxidative modification of low-density lipoproteins by mesangial cells. J Am Soc Nephrol. 1993 Aug;4(2):187-94.


Native LDL subjected to chemical oxidation by copper sulfate also inhibited mesangial cell proliferation.
0(0,0,0,0) Details
2188656 Fujita VS, Thiele DJ, Coon MJ: Expression of alcohol-inducible rabbit liver cytochrome P-450 3a (P-450IIE1) in Saccharomyces cerevisiae with the copper-inducible CUP1 promoter. DNA Cell Biol. 1990 Mar;9(2):111-8.

6(0,0,0,6) Details
11166292 Nelli S, McIntosh L, Martin W: Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta. Eur J Pharmacol. 2001 Feb 2;412(3):281-9.

2(0,0,0,2) Details
14622187 Mulero-Navarro S, Santiago-Josefat B, Pozo-Guisado E, Merino JM, Fernandez-Salguero PM: Down-regulation of CYP1A2 induction during the maturation of mouse cerebellar granule cells in culture: role of nitric oxide accumulation. Eur J Neurosci. 2003 Oct;18(8):2265-72.


Nitric oxide (NO) is responsible for cytochrome P450 (CYP450) loss during isolation and cytokine treatment of primary rat hepatocytes.
1(0,0,0,1) Details
6373031 Rannug A, Rannug U: Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimurium. Chem Biol Interact. 1984 May;49(3):329-40.


A further enhancement of the oxygen radical content of the cells by adding microsomes that produce oxygen radicals via autoxidation of cytochrome P-450 is proposed as the mechanism for the 'metabolic activation of TMTD '.
1(0,0,0,1) Details
18439880 Henczova M, Deer AK, Filla A, Komlosi V, Mink J: Effects of Cu (2+) and Pb (2+) on different fish species: liver cytochrome P450-dependent monooxygenase activities and FTIR spectra. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Jul;148(1):53-60. Epub 2008 Mar 18.

1(0,0,0,1) Details
2733697 De Matteis F, Trenti T, Gibbs AH, Greig JB: Inducible bilirubin-degrading system in the microsomal fraction of rat liver. Mol Pharmacol. 1989 Jun;35(6):831-8.

The hypothesis that treatment of Gunn rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates an alternative pathway of bilirubin disposal, involving an induced form of cytochrome P-450 [Proc.
Hematin, copper sulfate, and the iron chelate of EDTA were all active in promoting degradation of bilirubin in the presence of hydrogen peroxide.
1(0,0,0,1) Details