| Name | NMDA receptor (protein family or complex) |
|---|---|
| Synonyms | Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12763259 | Shimizu K, Matsubara K, Ohtaki K, Fujimaru S, Saito O, Shiono H: Paraquat induces long-lasting overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Res. 2003 Jun 27;976(2):243-52. The toxic mechanism of paraquat involves induced activation of non-NMDA receptors, resulting in activation of NMDA receptor-channels. |
81(1,1,1,1) | Details |
| 16081500 | Tauskela JS, Brunette E, O'Reilly N, Mealing G, Comas T, Gendron TF, Monette R, Morley P: An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics. FASEB J. 2005 Oct;19(12):1734-6. Epub 2005 Aug 4. Results from paraquat toxicity, intracellular fluorescence quenching, electrophysiology, mitochondrial Ca2+, and spontaneous synaptic activity experiments suggest a model in which metalloporphyrins, acting at the plasma membrane, protect neurons against OGD by suppressing postsynaptic NMDA receptor-mediated Ca2+ rises, thereby indirectly preventing accumulation of mitochondrial Ca2+ levels. |
31(0,1,1,1) | Details |
| 10889461 | Said SI, Pakbaz H, Berisha HI, Raza S: NMDA receptor activation: critical role in oxidant tissue injury. Free Radic Biol Med. 2000 Apr 15;28(8):1300-2. We report that NMDA receptor blocker MK-801 (dizocilpine attenuated oxidant injury induced by paraquat or by xanthine oxidase. |
8(0,0,1,3) | Details |
| 11520895 | Li QY, Pedersen C, Day BJ, Patel M: Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation. J Neurochem. 2001 Aug;78(4):746-55. OGD-induced mitochondrial aconitase inactivation and cell death was inhibited by tetrakis (4- (MnTBAP), tetrakis (N-ethylpyridinium-2-yl) (MnTE-2-PyP) and NMDA receptor antagonists. |
1(0,0,0,1) | Details |
| 17227436 | Goracke-Postle CJ, Overland AC, Stone LS, Fairbanks CA: transport into spinal nerve terminals is modulated by polyamine analogs. J Neurochem. 2007 Jan;100(1):132-41. The polyamine analogs paraquat and bis (guanylhydrazone) inhibited, whereas the polyamine transport enhancer difluoromethylornithine increased, [(3) H] transport. (decarboxylated is an endogenous amine found in the CNS that antagonizes NMDA receptors and inhibits synthase. |
1(0,0,0,1) | Details |