| Name | Bcl xL |
|---|---|
| Synonyms | Apoptosis regulator Bcl X; BCL XL/S; BCL2 like 1; BCL2 related gene; BCL2 like 1 isoform 1; BCL2L; BCL2L1; BCLX… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12654481 | Cheng WH, Quimby FW, Lei XG: Impacts of glutathione peroxidase-1 knockout on the protection by injected against the pro-oxidant-induced liver aponecrosis and signaling in -deficient mice. Free Radic Biol Med. 2003 Apr 1;34(7):918-27. The paraquat-mediated gene or protein expression of proapoptotic Bax, Bcl-w, and Bcl-X (S), cell survival/death factors GADD45, MDM2, c-Myc, and caspase-3 was upregulated, but that of antiapoptotic Bcl-2 was downregulated in the GPX1-/- mice vs. the WT mice. |
81(1,1,1,1) | Details |
| 15824117 | Thiruchelvam M, Prokopenko O, Cory-Slechta DA, Buckley B, Mirochnitchenko O: Overexpression of superoxide dismutase or peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem. 2005 Jun 10;280(23):22530-9. Epub 2005 Apr 11. Even a single injection of paraquat + maneb in the non-transgenic treated group modulated several key pro- and anti-apoptotic proteins, including Bax, Bad, Bcl-xL, and upstream stress-induced cascade. |
81(1,1,1,1) | Details |
| 10970895 | Asoh S, Ohtsu T, Ohta S: The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J Biol Chem. 2000 Nov 24;275(47):37240-5. When overexpressed in Jurkat cells, Bcl-xFNK was markedly more potent in prolonging survival following apoptosis-inducing treatment with a kind of cell death cytokines (anti-Fas), a protein kinase inhibitor (staurosporine), cell cycle inhibitors (TN-16, camptothecin, hydroxyurea, and trichostatin A), or oxidative stress peroxide and paraquat) than wild-type Bcl-x (L). |
37(0,1,1,7) | Details |
| 14578948 | Ohta S: [Development of the protein therapeutics using the super anti-cell death factor FNK]. J Nippon Med Sch. 2003 Oct;70(5):442-6. When overexpressed in Jurkat cells, FNK was markedly more potent in prolonging survival following apoptosis-inducing treatment with a kind of cell death cytokines (anti-Fas), a protein kinase inhibitor (staurosporine), cell cycle inhibitors (TN-16, camptothecin, hydroxyurea and trichostatin A) or oxidative stress peroxide and paraquat) than wild-type Bcl-xL. |
36(0,1,1,6) | Details |
| 10421577 | Mitsuhara I, Malik KA, Miura M, Ohashi Y: Animal cell-death suppressors Bcl-x (L) and Ced-9 inhibit cell death in tobacco plants. Curr Biol. 1999 Jul 15;9(14):775-8. In plants expressing Bcl-x (L), cell death induced by UV-B irradiation, paraquat treatment or the hypersensitive reaction (HR) to tobacco mosaic virus (TMV) infection was suppressed. |
35(0,1,1,5) | Details |
| 17891400 | Chu Y, Deng XY, Faustinelli P, Ozias-Akins P: Bcl-xL transformed peanut (Arachis hypogaea L.) exhibits paraquat tolerance. Plant Cell Rep. 2008 Jan;27(1):85-92. Epub 2007 Sep 22. |
12(0,0,1,7) | Details |
| 12354917 | Qiao J, Mitsuhara I, Yazaki Y, Sakano K, Gotoh Y, Miura M, Ohashi Y: Enhanced resistance to salt, cold and wound stresses by overproduction of animal cell death suppressors Bcl-xL and Ced-9 in tobacco cells - their possible contribution through improved function of organella. Plant Cell Physiol. 2002 Sep;43(9):992-1005. Overproduction of animal cell death suppressors Bcl-xL and Ced-9 conferred enhanced resistance to UV-B and paraquat treatment in tobacco plants [Mitsuhara et al. (1999) CURR: Biol. 9: 775]. |
8(0,0,1,3) | Details |
| 18266926 | Fei Q, Ethell DW: Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members. J Neurochem. 2008 Mar 11. Focusing on mechanisms responsible for this synergy, we found that maneb+PQ increased the expression of three strong Bak inhibitors, Bfl-1, Bcl-xL and Mcl-1, and also induced Bax activators that included Bik and Bim. |
1(0,0,0,1) | Details |
| 16797015 | Dragin N, Smani M, Arnaud-Dabernat S, Dubost C, Moranvillier I, Costet P, Daniel JY, Peuchant E: Acute oxidative stress is associated with cell proliferation in the mouse liver. FEBS Lett. 2006 Jul 10;580(16):3845-52. Epub 2006 Jun 15. To investigate the molecular events linked to acute oxidative stress in mouse liver, we injected a toxic dose of paraquat. Concomitantly, activation of the MAP kinase pathway and increased levels of the anti-apoptotic protein Bcl-XL were observed. |
1(0,0,0,1) | Details |