| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19715754 | Zaidi A, Fernandes D, Bean JL, Michaelis ML: Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca (2+)-ATPase. Free Radic Biol Med. 2009 Nov 15;47(10):1507-14. Epub 2009 Aug 26. |
7(0,0,1,2) | Details |
| 15133895 | Wang JM, Li HQ, Pan XP, Li MR: [Effect of methyl viologen on the Ca (2+)-ATPase activities of membrane vesicles in roots of rice seedlings]. Shi Yan Sheng Wu Xue Bao. 2004 Feb;37(1):29-33. |
4(0,0,0,4) | Details |
| 11251816 | Nachin L, El Hassouni M, Loiseau L, Expert D, Barras F: SoxR-dependent response to oxidative stress and virulence of Erwinia chrysanthemi: the key role of SufC, an orphan ABC ATPase. Mol Microbiol. 2001 Feb;39(4):960-72. In addition, inactivation of sufC and sufD led to increased sensitivity to paraquat. |
3(0,0,0,3) | Details |
| 17144312 | Chiang HC, Lo JC, Yeh KC: Genes associated with heavy metal tolerance and accumulation in Zn/Cd hyperaccumulator Arabidopsis halleri: a genomic survey with cDNA microarray. Environ Sci Technol. 2006 Nov 1;40(21):6792-8. We found that metallothionein 2b and 3, APX and MDAR4 in the - pathway, and certain metal transporters in P (1B)-type ATPase, ZIP, Nramp, and CDF families, are expressed at higher levels in A. halleri than in A. thaliana. This observation positively correlates with the higher ability of A. halleri to detoxify H2O2 produced by cadmium and paraquat treatments. |
1(0,0,0,1) | Details |
| 19594831 | Prosecka J, Orlov AV, Fantin YS, Zinchenko VV, Babykin MM, Tichy M: A novel ATP-binding cassette transporter is responsible for resistance to viologen herbicides in the cyanobacterium Synechocystis sp. FEBS J. 2009 Aug;276(15):4001-11. Epub 2009 Jul 7. Bioinformatic analysis showed that in various bacterial genomes, two genes encoding another permease subunit and the ATPase component of an ATP-binding cassette transporter form putative operons with slr1174 orthologs, suggesting that the protein products of these genes may form functional transporters. |
1(0,0,0,1) | Details |
| 17077588 | Satomi Y, Tsuchiya W, Miura D, Kasahara Y, Akahori F: DNA microarray analysis of pulmonary fibrosis three months after exposure to paraquat in rats. J Toxicol Sci. 2006 Oct;31(4):345-55. The products of these genes were: CSF-1 receptor, which is a receptor of inflammatory cytokines that activates monocyte/macrophages; TGF-beta type II receptor, which is a receptor of TGF-betas involved in wound healing and fibrosis; a subunit of Na+/K (+)-ATPase, an amiloride-sensitive cation channel, and a subunit of the potassium channel, all of which regulate the alveolar fluid balance and play a role in clearing lung edema; the adenosine A2a receptor, which has a protective function in the lung and interacts with D1 and D2 receptors to regulate the function of amiloride-sensitive cation channels; cofilin, which is involved in the depolymerization and cleavage of actin filaments; LIM motif-containing protein kinase 1, which negatively regulates the activity of cofilin; SHPS-1, which regulates the integrin-mediated reorganization of the cytoskeleton; and sodium channel beta 2, which is involved in cell adhesion and migration. |
1(0,0,0,1) | Details |
| 10356780 | Tabata N, Morita M, Mimasaka S, Funayama M, Hagiwara T, Abe M: Paraquat myopathy: report on two suicide cases. Forensic Sci Int. 1999 Mar 15;100(1-2):117-26. The following sarcoplasmic or endoplasmic reticulum Ca2+ ATPase (SERCA) monoclonal antibodies were used for skeletal muscle fiber typing by an immunohistochemical method: NCL-SERCA1, reactive with type 2 fiber (fast-twitch), and NCL-SERCA2, reactive with type 1 fiber (slow-twitch). |
1(0,0,0,1) | Details |
| 15944174 | Yoshinaga K, Arimura S, Niwa Y, Tsutsumi N, Uchimiya H, Kawai-Yamada M: Mitochondrial behaviour in the early stages of ROS stress leading to cell death in Arabidopsis thaliana. Ann Bot. 2005 Aug;96(2):337-42. Epub 2005 Jun 8. METHODS: Arabidopsis leaves were treated with ROS and ROS-inducing chemicals such as peroxide, paraquat and Treatment of leaves with monoxime, an inhibitor of myosin ATPase, resulted in similar behaviour of mitochondria to that under ROS stress. |
1(0,0,0,1) | Details |
| 16555045 | Tomita M, Okuyama T, Katsuyama H, Ishikawa T: Paraquat-induced gene expression in rat kidney. . Arch Toxicol. 2006 Oct;80(10):687-93. Epub 2006 Mar 23. Expression of six genes had increased significantly by 3 h after the first injection: metallothionein-1 (MT-1), phosphoenolpyruvate carboxykinase, Na/K-transporting ATPase beta1 subunit, oxaloacetic transaminase, glutathione-S-transferase, and heme oxygenase-1 (HO-1). |
1(0,0,0,1) | Details |
| 19542013 | Figtree GA, Liu CC, Bibert S, Hamilton EJ, Garcia A, White CN, Chia KK, Cornelius F, Geering K, Rasmussen HH: Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009 Jul 17;105(2):185-93. Epub 2009 Jun 18. ONOO (-) also induced glutathionylation of the Na (+)-K (+) ATPase beta (1) subunit from pig kidney. We detected glutathionylation of beta (1), but not alpha (1), subunits in rabbit ventricular myocytes at baseline. beta (1) Subunit glutathionylation was increased by (ONOO (-)), paraquat, or activation of oxidase by Ang II. |
1(0,0,0,1) | Details |
| 17934957 | Yang W, Tiffany-Castiglioni E: The bipyridyl herbicide paraquat induces proteasome dysfunction in human neuroblastoma SH-SY5Y cells. J Toxicol Environ Health A. 2007 Nov;70(21):1849-57. In addition, the cells showed decreased ATP levels and reduced mitochondrial complex V activity. |
1(0,0,0,1) | Details |
| 15019097 | Kondoh M, Tsukada M, Kuronaga M, Higashimoto M, Takiguchi M, Himeno S, Watanabe Y, Sato M: Induction of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice. Toxicol Lett. 2004 Mar 14;148(1-2):133-9. Metallothionein (MT) is a small sulfhydryl-rich protein whose levels are elevated by various inducers of organelle stresses, such as nuclear stress (cisplatin), mitochondrial stress (antimycin A, 2,4-dinitrophenol) and lysosomal stress (paraquat). Thapsigargin (Thap), a generator of ER stress by inhibiting ER Ca (2+)-ATPase, also increased both hepatic MT levels and expression of MT-I and -II mRNA. |
1(0,0,0,1) | Details |
| 17823202 | Yang W, Chen L, Ding Y, Zhuang X, Kang UJ: Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum Mol Genet. 2007 Dec 1;16(23):2900-10. Epub 2007 Sep 6. |
0(0,0,0,0) | Details |
| 17176259 | Bishop AL, Rab FA, Sumner ER, Avery SV: Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Mol Microbiol. 2007 Jan;63(2):507-20. Epub 2006 Dec 14. The mutants (e.g. vma3, ctr1, sod1) exhibited the anticipated sensitivities to intermediate doses of alkaline pH, or paraquat. |
0(0,0,0,0) | Details |